Results 1 to 10 of about 7,548 (208)

Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications [PDF]

Toxins, 2016
Clostridium perfringens enterotoxin (CPE) is responsible for causing the gastrointestinal symptoms of several C. perfringens food- and nonfood-borne human gastrointestinal diseases. The enterotoxin gene (cpe) is located on either the chromosome (for most
John C. Freedman, Archana Shrestha, Bruce A. McClane   +2 more
doaj   +6 more sources

Processing of Clostridium perfringens Enterotoxin by Intestinal Proteases [PDF]

Toxins
C. perfringens type F isolates are a leading cause of food poisoning and antibiotic-associated diarrhea. Type F isolate virulence requires production of C.
Archana Shrestha, Jessica L. Gonzales, Juliann Beingesser, Francisco A. Uzal, Bruce A. McClane   +4 more
doaj   +5 more sources

NanI Sialidase Enhances the Action of Clostridium perfringens Enterotoxin in the Presence of Mucus [PDF]

mSphere, 2021
Clostridium perfringens enterotoxin (CPE) is the main virulence factor for C. perfringens type F strains to cause human gastrointestinal diseases, which can involve lethal enterotoxemia.
Mauricio A. Navarro, Jihong Li, Juliann Beingesser, Bruce A. McClane, Francisco A. Uzal   +4 more
doaj   +2 more sources

Comparative Genome Analysis and Spore Heat Resistance Assay Reveal a New Component to Population Structure and Genome Epidemiology Within Clostridium perfringens Enterotoxin-Carrying Isolates [PDF]

Frontiers in Microbiology, 2021
Clostridium perfringens causes a variety of human and animal enteric diseases including food poisoning, antibiotic-associated diarrhea, and necrotic enteritis. Yet, the reservoirs of enteropathogenic enterotoxin-producing strains remain unknown.
Kaisa Jaakkola, Kira Virtanen, Kira Virtanen, Päivi Lahti, Riikka Keto-Timonen, Miia Lindström, Hannu Korkeala   +6 more
doaj   +2 more sources

Rapid eradication of colon carcinoma by Clostridium perfringens Enterotoxin suicidal gene therapy. [PDF]

BMC Cancer, 2017
Background Bacterial toxins have evolved to an effective therapeutic option for cancer therapy. The Clostridium perfringens enterotoxin (CPE) is a pore- forming toxin with selective cytotoxicity. The transmembrane tight junction proteins claudin-3 and -4
Pahle J, Menzel L, Niesler N, Kobelt D, Aumann J, Rivera M, Walther W.   +6 more
europepmc   +7 more sources

Probing Genomic Aspects of the Multi-Host Pathogen Clostridium perfringens Reveals Significant Pangenome Diversity, and a Diverse Array of Virulence Factors [PDF]

Frontiers in Microbiology, 2017
Clostridium perfringens is an important cause of animal and human infections, however information about the genetic makeup of this pathogenic bacterium is currently limited.
Raymond Kiu, Raymond Kiu, Shabhonam Caim, Sarah Alexander, Purnima Pachori, Lindsay J. Hall   +5 more
doaj   +4 more sources

Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells. [PDF]

Int J Mol Sci, 2019
Claudins regulate paracellular permeability in different tissues. The claudin-binding domain of Clostridium perfringens enterotoxin (cCPE) is a known modulator of a claudin subset. However, it does not efficiently bind to claudin-1 (Cldn1).
Beier LS, Rossa J, Woodhouse S, Bergmann S, Kramer HB, Protze J, Eichner M, Piontek A, Vidal-Y-Sy S, Brandner JM, Krause G, Zitzmann N, Piontek J.   +12 more
europepmc   +4 more sources

Identification of novel clostridium perfringens type E strains that carry an iota toxin plasmid with a functional enterotoxin gene [PDF]

, 2011
Clostridium perfringens enterotoxin (CPE) is a major virulence factor for human gastrointestinal diseases, such as food poisoning and antibiotic associated diarrhea. The CPE-encoding gene (cpe) can be chromosomal or plasmid-borne.
A Deguchi, A Gurjar, A Heikinheimo, BA McClane, Bruce A. McClane, D Lepp, Herman Tse, HS Garmony, J Li, J Li, J Li, J Li, J Li, JA Parsons, Jihong Li, K Miyamoto, K Miyamoto, K Miyamoto, K Miyamoto, Kanako Mimura, Kazuaki Miyamoto, KH Harry, Masahiro Nagahama, MR Sarker, Natsuko Yumine, S Sayeed, S Sayeed, Shigeru Akimoto, SJ Billington, SR Mueller-Spits, T Hirokawa, Y Miki, Y Zhao   +32 more
core   +27 more sources

Current notions about etiopathogenic and genetics specific features of Сlostridium perfringens toxins

Журнал микробиологии, эпидемиологии и иммунобиологии, 2021
The review presents modern data on the genetics and etiopathogenetic features of Clostridium perfringens toxins, including the role of Clostridium perfringens enterotoxin, in the development of food poisoning and a number of intestinal diseases in humans,
Yu. V. Lobzin, A. S. Kvetnaya, N. V. Skripchenko, L. I. Zhelezova   +3 more
doaj   +1 more source

NetB negative Clostridium perfringens infection associated with acute necrotic enteritis in mynah (Acridotheres tristis), grey partridge (Perdix perdix) and turkey (Meleagris gallopavo) [PDF]

The Iranian Journal of Veterinary Science and Technology, 2017
A non–enterotoxin (CPE)–producing Clostridium perfringens type A, associated with enteritis in a mynah (Acridotheres tristis), a grey partridge (Perdix perdix) and a turkey (Meleagris gallopavo) was characterized from cases with clinical symptoms from ...
Jamshid Razmyar, Massoud Rezaee, Ahmad Reza Movassaghi, Bahram Shojadust   +3 more
doaj   +1 more source