Results 71 to 80 of about 23,272 (312)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

$r$-fuzzy regular semi open sets in smooth topological spaces [PDF]

Sahand Communications in Mathematical Analysis, 2017
In this paper, we introduce and study the concept of $r$-fuzzy regular semi open (closed) sets in smooth topological spaces. By using $r$-fuzzy regular semi open (closed) sets, we define a new fuzzy closure operator namely $r$-fuzzy regular semi interior
Appachi Vadivel, Elangovan Elavarasan
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Fuzzy θ-closure operator on fuzzy topological spaces

International Journal of Mathematics and Mathematical Sciences, 1991
The paper contains a study of fuzzy θ-closure operator, θ-closures of fuzzy sets in a fuzzy topological space are characterized and some of their properties along with their relation with fuzzy δ-closures are investigated.
M. N. Mukherjee, S. P. Sinha
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Closure Operators and Lattice Extensions [PDF]

Order, 2004
Let \(\Gamma \) be a closure operator on a set \(X\). Then Cl\((X,\Gamma )\) denotes the lattice of \(\Gamma \)-closed subsets of \(X\). If \(\Gamma \) and \(\Delta \) are closure operators on the same set \(X\), then \(\Delta \) is a weak (resp. strong) extension of \(\Gamma \) if Cl\((X,\Gamma )\) is a complete meet-subsemilattice (resp.
openaire   +2 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Characterization of neighborhood operators based on neighborhood relationships

Journal of Intelligent Systems
Neighborhood relationships play a pivotal role in rough set theory, addressing the limitations of equivalence relations. This article focuses on defining upper and lower approximation operators using neighborhood relationships and exploring their ...
Caixin Wei, Pei Wang, Rongrong Xu, Wanyuan Huang   +3 more
doaj   +1 more source

A New Approach to the Fuzzification of Convex Structures

Journal of Applied Mathematics, 2014
A new approach to the fuzzification of convex structures is introduced. It is also called an M-fuzzifying convex structure. In the definition of M-fuzzifying convex structure, each subset can be regarded as a convex set to some degree.
Fu-Gui Shi, Zhen-Yu Xiu
doaj   +1 more source

Spatial logic of modal mu-calculus and tangled closure operators [PDF]

, 2016
Robert Goldblatt, Ian Hodkinson
openalex   +1 more source