Results 71 to 80 of about 23,371 (266)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Dynamics of Resource Closure Operators [PDF]
, 2009 We propose a framework for managing resources via convergent operators. Operators represent their need for a resource to a designated resource closure operator that manages the resource. We evaluate a specific design for a resource closure operator by simulation and demonstrate that the operator achieves a near-optimal balance between cost and value ...
Alva L. Couch, Marc Chiarini
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Theoretical Properties of Closed Frequent Itemsets in Frequent Pattern Mining
MathematicsClosed frequent itemsets (CFIs) play a crucial role in frequent pattern mining by providing a compact and complete representation of all frequent itemsets (FIs).
Huina Zhang +4 more
doaj +1 more source
$r$-fuzzy regular semi open sets in smooth topological spaces [PDF]
Sahand Communications in Mathematical Analysis, 2017 In this paper, we introduce and study the concept of $r$-fuzzy regular semi open (closed) sets in smooth topological spaces. By using $r$-fuzzy regular semi open (closed) sets, we define a new fuzzy closure operator namely $r$-fuzzy regular semi interior
Appachi Vadivel, Elangovan Elavarasan
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Fuzzy θ-closure operator on fuzzy topological spaces
International Journal of Mathematics and Mathematical Sciences, 1991 The paper contains a study of fuzzy θ-closure operator, θ-closures of fuzzy sets in a fuzzy topological space are characterized and some of their properties along with their relation with fuzzy δ-closures are investigated.
M. N. Mukherjee, S. P. Sinha
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source