Results 71 to 80 of about 759,634 (294)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Parametric Closed Classes of Hyperfunctions on Two-Element Set

Известия Иркутского государственного университета: Серия "Математика", 2016
One of the direction in discrete function's investigations is research of functional systems: the sets of functions and the sets of operators defined on this functions.
L. Ryabets
doaj  

The characterizations of upper approximation operators based on special coverings

Open Mathematics, 2017
In this paper, we discuss the approximation operators apr¯NS${\overline {apr} _{NS}}$ and apr¯S${\overline {apr} _S}$ which are based on NS(U) and S.
Wang Pei, Li Qingguo
doaj   +1 more source

All about unambiguous polynomial closure [PDF]

TheoretiCS
We study a standard operator on classes of languages: unambiguous polynomial closure. We prove that for every class C of regular languages satisfying mild properties, the membership problem for its unambiguous polynomial closure UPol(C) reduces to the ...
Thomas Place, Marc Zeitoun
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Dynamics of Resource Closure Operators [PDF]

, 2009
We propose a framework for managing resources via convergent operators. Operators represent their need for a resource to a designated resource closure operator that manages the resource. We evaluate a specific design for a resource closure operator by simulation and demonstrate that the operator achieves a near-optimal balance between cost and value ...
Alva L. Couch, Marc Chiarini
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Classification of Multioperations of Rank 2 by E-precomplete Sets

Известия Иркутского государственного университета: Серия "Математика", 2020
In this paper multioperations defined on a two-element set and their closure operator based on composition operator and the equality predicate branching operator is considered. The composition operator is based on union of sets.
V.I. Panteleev, L.V. Ryabets
doaj   +1 more source

Amplatzer device closure of an inferior venosus atrial septal defect after surgical closure of a secundum atrial septal defect [PDF]

, 2004
This article presents a patient who had transcatheter closure of a low atrial septal defect which was overlooked during surgical closure of a secundum atrial septal defect.
DeGiovanni, Joseph V., Grech, Victor E., Falzon, A.   +2 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source