Results 41 to 50 of about 91,871 (338)

Routine data linkage to identify and monitor diabetes in clozapine-treated patients with schizophrenia [PDF]

, 2016
No abstract ...
Connolly, M., Gareze, J., Langan-Martin, J., Mackay, D., McLean, G., Park, J., Pearsall, R., Smith, D.J., Walker, A.   +8 more
core   +1 more source

Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice

Scientific Reports, 2019
Muscarinic Designer Receptors Exclusively Activated by Designer Drugs (DREADD) gated by clozapine-N-oxide (CNO) allow selective G-protein cascade activation in genetically specified cell-types in vivo.
Martin M Jendryka, M. Palchaudhuri, D. Ursu, Bastiaan van der Veen, B. Liss, D. Kätzel, Wiebke Nissen, A. Pekcec   +7 more
semanticscholar   +1 more source

Obesity treatment initiation, retention, and outcomes in the Veterans Affairs MOVE! Program among rural and urban veterans

Obesity Science &Practice, Volume 8, Issue 6, Page 784-793, December 2022., 2022
Abstract Objective Rural veterans have high obesity rates. Yet, little is known about this population's engagement with the Veterans Affairs (VA) weight management program (MOVE!). The study objective is to determine whether MOVE! enrollment, anti‐obesity medication use, bariatric surgery use, retention, and outcomes differ by rurality for veterans ...
Kathleen M. Robinson, Mark Vander Weg, Helena H. Laroche, Margaret Carrel, Jason Wachsmuth, Krista Kazembe, Mary Vaughan Sarrazin   +6 more
wiley   +1 more source

Reasons for admission to a general medical hospital for patients taking clozapine

Therapeutic Advances in Psychopharmacology, 2022
Background: Clozapine is associated with a diverse range of side effects. In addition, patients prescribed clozapine commonly suffer with medical comorbidities.
Siobhan Gee, Vasco Almeida, Adam Hughes, Isabel McMullen, David Taylor   +4 more
doaj   +1 more source

Patterns of clozapine use, misuse and disuse in a mental health area in southern Spain

European Psychiatry, 2022
Introduction Evidence supports clozapine as the best treatment in terms of efficacy, effectiveness and well-being, and as the gold standard in treatment-resistant psychotic disorders. Clozapine remains still underused, suffering initiation delays from 1.
L.I. Muñoz-Manchado, J.M. Mongil-Sanjuan, J.M. Pascual Paño, C. Rodríguez-Gómez, R. Torrecilla-Olavarrieta, J.I. Pérez-Revuelta, F. González-Saiz, J.M. Villagrán-Moreno   +7 more
doaj   +1 more source

Cannabis and schizophrenia [PDF]

, 2014
BACKGROUND Schizophrenia is a mental illness causing disordered beliefs, ideas and sensations. Many people with schizophrenia smoke cannabis, and it is unclear why a large proportion do so and if the effects are harmful or beneficial. It is also unclear
Gillies, Donna, Kalakouti, Eliana, Kyprianou, Katerina, McLoughlin, Benjamin C., Pushpa-Rajah, Jonathan A., Rathbone, John, Variend, Hannele   +6 more
core   +1 more source

The DREADD agonist clozapine N-oxide (CNO) is reverse-metabolized to clozapine and produces clozapine-like interoceptive stimulus effects in rats and mice

Scientific Reports, 2018
Clozapine-N-oxide (CNO) has long been the ligand of choice for selectively activating Designer Receptors Exclusively Activated by Designer Drugs (DREADDs).
D. F. Manvich, Kevin A. Webster, S. Foster, M. Farrell, J. Ritchie, J. Porter, D. Weinshenker   +6 more
semanticscholar   +1 more source

Clozapine Combination and Augmentation Strategies in Patients With Schizophrenia -Recommendations From an International Expert Survey Among the Treatment Response and Resistance in Psychosis (TRRIP) Working Group.

Schizophrenia bulletin, 2020
BACKGROUND Evidence for the management of inadequate clinical response to clozapine in treatment-resistant schizophrenia is sparse. Accordingly, an international initiative was undertaken with the aim of developing consensus recommendations for treatment
E. Wagner, J. Kane, C. Correll, O. Howes, D. Siskind, W. Honer, Jimmy Lee, P. Falkai, T. Schneider-Axmann, A. Hasan   +9 more
semanticscholar   +1 more source

Infections associated with clozapine: a pharmacovigilance study using VigiBase®

Frontiers in Pharmacology, 2023
Introduction: Clozapine is primarily reserved for treatment-resistant schizophrenia due to safety concerns associated with its use. Infections have been reported with clozapine, which may lead to elevated serum levels of the drug.
Basile Chrétien, Perrine Brazo, Perrine Brazo, Angélique Da Silva, Marion Sassier, Charles Dolladille, Charles Dolladille, Véronique Lelong-Boulouard, Véronique Lelong-Boulouard, Joachim Alexandre, Joachim Alexandre, Sophie Fedrizzi   +11 more
doaj   +1 more source

Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogenous time-resolved FRET [PDF]

, 2010
Flp-In T-REx 293 cells expressing a wild type human M muscarinic acetylcholine receptor construct constitutively and able to express a Receptor Activated Solely by Synthetic Ligand (RASSL) form of this receptor on demand maintained response to the ...
Alvarez-Curto, Elisa, Milligan, Graeme, Pediani, John D., Ward, Richard J.   +3 more
core   +2 more sources