Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis
mBio, 2023 Bacterial AAA+ unfoldases are crucial for bacterial physiology by recognizing specific substrates and, typically, unfolding them for degradation by a proteolytic component. The caseinolytic protease (Clp) system is one example where a hexameric unfoldase
Stefan Pan +7 more
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mSystems, 2021 The cellular proteome comprises all proteins expressed at a given time and defines an organism’s phenotype under specific growth conditions. The proteome is shaped and remodeled by both protein synthesis and protein degradation.
Marlène S. Birk +5 more
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Bioinformatic identification of ClpI, a distinct class of Clp unfoldases in Actinomycetota [PDF]
Frontiers in Microbiology, 2023 All clades of bacteria possess Hsp100/Clp family unfoldase enzymes that contribute to aspects of protein quality control. In Actinomycetota, these include ClpB, which functions as an independent chaperone and disaggregase, and ClpC, which cooperates with
Jialiu Jiang +2 more
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Advanced ScienceChloroplast division is essential for plant growth and photosynthesis, and the assembly of the FtsZ‐ring is tightly regulated by ARC3 (ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3). However, the mechanisms controlling its protein turnover remain poorly
Yang Yuan +5 more
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Genome analysis screening virulence genes for the altered pathogenicity of Riemerella anatipestifer in hens [PDF]
Frontiers in MicrobiologyBackgroundIn recent years, Riemerella anatipestifer infection in chickens has markedly increased, resulting in substantial economic losses to the poultry industry. The present study was designed to assess the pathogenicity of R.
Junfeng Lv +13 more
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MecA in Streptococcus mutans is a multi-functional protein [PDF]
mSphereOur recent studies have shown that deficiency of MecA in Streptococcus mutans significantly affects cell division, growth, and biofilm formation. In this study, an in vitro mixed-species model, proteomics, and affinity pull-down assays were used to ...
Kassapa Ellepola +6 more
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Unveiling Prophage Diversity and Host Interactions in Liberibacter: Genomic Insights for Phage Therapy Against Citrus Huanglongbing [PDF]
BiologyHLB is a severe and devastating disease affecting citrus plants, for which no cure is currently available. The pathogen CLas is an unculturable, phloem-limited α-proteobacterium associated with HLB.
Hui Yin +5 more
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Infant-Type Bifidobacteria as Biocontrol Agents: Suppressing Listeria monocytogenes via Key Virulence Gene Alteration [PDF]
Canadian Journal of Infectious Diseases and Medical MicrobiologyInfant-type bifidobacteria exhibit potential as targeted biocontrol agents against Listeria monocytogenes infections. However, the strain-specific antimicrobial efficacy and molecular mechanisms remain insufficiently characterized.
Qianglai Tan +6 more
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Dynamic Shifts in ER-Plasma Membrane Junctions Signaling Define Pro-Metastatic N-Glycosylation and Predict Prostate Cancer Progression. [PDF]
Adv Sci (Weinh)Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Macke AJ +14 more
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An NMR Study on the clpC Operon Binding Region of Transcription Factor CtsR from Bacillus subtilis
Chinese Journal of Magnetic Resonance, 2021 When Gram-positive bacterium Bacillus subtilis responds to heat-shock, protein arginine kinase McsB phosphorylates Arg62 (R) in the clpC operon binding region of transcription factor CtsR, leading to dissociation of CtsR and clpC operon and initiation of
CHEN Xiao-wen +3 more
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