Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. [PDF]
PLoS Pathogens, 2014 Unlike most bacterial species, Mycobacterium tuberculosis depends on the Clp proteolysis system for survival even in in vitro conditions. We hypothesized that Clp is required for the physiologic turnover of mycobacterial proteins whose accumulation is ...
Ravikiran M Raju +9 more
doaj +7 more sources
Role of Hsp100/Clp protease complexes in controlling the regulation of motility in Bacillus subtilis [PDF]
Frontiers in Microbiology, 2016 The Hsp100/Clp protease complexes of Bacillus subtilis ClpXP and ClpCP are involved in the control of many interconnected developmental and stress response regulatory networks, including competence, redox stress response and motility.
Noel eMoliere +3 more
doaj +6 more sources
Clp protease and antisense RNA jointly regulate the global regulator CarD to mediate mycobacterial starvation response [PDF]
eLife, 2022 Under starvation conditions, bacteria tend to slow down their translation rate by reducing rRNA synthesis, but the way they accomplish that may vary in different bacteria. In Mycobacterium species, transcription of rRNA is activated by the RNA polymerase
Xinfeng Li +9 more
doaj +2 more sources
PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum [PDF]
Cell Reports, 2017 Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin +7 more
doaj +2 more sources
Co-Suppression of NbClpC1 and NbClpC2, Encoding Clp Protease Chaperons, Elicits Significant Changes in the Metabolic Profile of Nicotiana benthamiana [PDF]
Plants, 2020 Metabolites in plants are the products of cellular metabolic processes, and their differential amount can be regarded as the final responses of plants to genetic, epigenetic, or environmental stresses. The Clp protease complex, composed of the chaperonic
Md. Sarafat Ali, Kwang-Hyun Baek
doaj +2 more sources
Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis. [PDF]
PLoS Genetics, 2017 Disruption of protein homeostasis in chloroplasts impairs the correct functioning of essential metabolic pathways, including the methylerythritol 4-phosphate (MEP) pathway for the production of plastidial isoprenoids involved in photosynthesis and growth.
Ernesto Llamas +2 more
doaj +2 more sources
Self-resistance mechanism to acyldepsipeptide antibiotics in the Streptomyces producer [PDF]
mBioClp proteases are ubiquitous in bacteria and play an important role in regulatory proteolysis and in maintaining protein homeostasis within the bacterial cell. They consist of a tetradecameric, proteolytic ClpP core and associated AAA+ Clp-ATPases.
Dhana Thomy +6 more
doaj +2 more sources
BacPROTACs targeting Clp protease: a promising strategy for anti-mycobacterial drug discovery [PDF]
Frontiers in ChemistryTuberculosis (TB) has claimed more lives over the course of two millennia than any other infectious disease worldwide. In 2021, the World Health Organization (WHO) estimated that 10.6 million people were diagnosed with TB, resulting in the deaths of 1.4 ...
Andressa Francielli Bonjorno +6 more
doaj +2 more sources
Mechanism of Gzma-mediated GEF-H1 activation in intestinal epithelial cells leading to intestinal barrier dysfunction in sepsis. [PDF]
Clin Transl MedAbstract Background Sepsis‐induced intestinal injury is a severe complication associated with dysfunction affecting multiple organ systems and a significantly elevated risk of death. Intestinal barrier dysfunction plays a central role, but the underlying molecular pathways remain incompletely understood. The present study sought to explore how the Gzma/
Lin Z +18 more
europepmc +2 more sources
Differential contributions of ClpX and ClpP to pulmonary virulence in classical and hypervirulent Klebsiella pneumoniae [PDF]
Infection and ImmunityKlebsiella pneumoniae is an opportunistic Gram-negative pathogen and a common cause of antibiotic-resistant infections including neonatal sepsis and hospital-acquired pneumonia. K.
Nathan M. Lin +3 more
doaj +2 more sources