Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening. [PDF]
J Exp Bot, 2018 Profound metabolic and structural changes are required for fleshy green fruits to ripen and become colorful and tasty. In tomato (Solanum lycopersicum), fruit ripening involves the differentiation of chromoplasts, specialized plastids that accumulate ...
D'Andrea L +7 more
europepmc +2 more sources
mBio, 2022 Clp proteases consist of a proteolytic, tetradecameric ClpP core and AAA+ Clp-ATPases. Streptomycetes, producers of a plethora of secondary metabolites, encode up to five different ClpP homologs, and the composition of their unusually complex Clp ...
Laura Reinhardt +7 more
doaj +1 more source
Generation and characterization of a collection of knock-down lines for the chloroplast Clp protease complex in tobacco. [PDF]
J Exp Bot, 2017 Protein degradation in chloroplasts is carried out by a set of proteases that eliminate misfolded, damaged, or superfluous proteins. The ATP-dependent caseinolytic protease (Clp) is the most complex protease in plastids and has been implicated mainly in ...
Moreno JC +6 more
europepmc +2 more sources
Both Hsp70 chaperone and Clp protease plastidial systems are required for protection against oxidative stress. [PDF]
Plant Signal Behav, 2017 Environmental stress conditions such as high light, extreme temperatures, salinity or drought trigger oxidative stress and eventually protein misfolding in plants.
Pulido P +2 more
europepmc +2 more sources
Where Proteins Go to Die: Elucidating the Physiological and Therapeutic Significance of the Clp Protease Complex in Mycobacterium Tuberculosis [PDF]
, 2014 Microbiologists have long focused on transcription as a main source of physiological regulation in bacterial adaptation. However, the time scale on which certain cellular responses must be coordinated dictates that a more rapid system be in place to deal
Raju, Ravikiran
core +6 more sources
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. [PDF]
PLoS Pathogens, 2012 In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes ...
Ravikiran M Raju +7 more
doaj +1 more source
Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1
Microbiology Spectrum, 2023 The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen.
Emmanuel C. Ogbonna +4 more
doaj +1 more source
Involvement of ClpE ATPase in Physiology of Streptococcus mutans
Microbiology Spectrum, 2021 Streptococcus mutans, a dental pathogen, harbors at least three Clp ATPases (ClpC, ClpE, and ClpX) that form complexes with ClpP protease and participate in regulated proteolysis. Among these, the function of ClpE ATPase is poorly understood.
Saswati Biswas +3 more
doaj +1 more source
Molecules, 2021 CLP is a novel hybrid peptide derived from CM4, LL37 and TP5, with significantly reduced hemolytic activity and increased antibacterial activity than parental antimicrobial peptides.
Junhao Cheng +10 more
doaj +1 more source
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury. [PDF]
Adv Sci (Weinh)This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Liang H +7 more
europepmc +2 more sources