Results 21 to 30 of about 17,783 (200)

Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. [PDF]

PLoS Pathogens, 2012
In most bacteria, Clp protease is a conserved, non-essential serine protease that regulates the response to various stresses. Mycobacteria, including Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis, unlike most well studied prokaryotes ...
Ravikiran M Raju, Meera Unnikrishnan, Daniel H F Rubin, Vidhya Krishnamoorthy, Olga Kandror, Tatos N Akopian, Alfred L Goldberg, Eric J Rubin   +7 more
doaj   +1 more source

Interactome Analysis Identifies MSMEI_3879 as a Substrate of Mycolicibacterium smegmatis ClpC1

Microbiology Spectrum, 2023
The prevalence of drug-resistant Mycobacterium tuberculosis infections has prompted extensive efforts to exploit new drug targets in this globally important pathogen.
Emmanuel C. Ogbonna, Henry R. Anderson, Patrick C. Beardslee, Priyanka Bheemreddy, Karl R. Schmitz   +4 more
doaj   +1 more source

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities [PDF]

, 2013
PMCID: PMC3613350This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Bellier, A Milano, A Singh, A Wawrzynow, AM Sherrid, AM Socha, Amanda C. Brown, Anil Kumar Tyagi, CA Pashley, D Weichart, DG Muttucumaru, DL Schuessler, Dorothée L. Schuessler, E Kruger, GR Stewart, H Brotz-Oesterhelt, H Ingvarsson, HI Boshoff, I Levchenko, J Braman, J Kirstein, J Ollinger, J Porankiewicz, JB Andersen, JH Kim, JM Flynn, LE Thomsen, LG Wayne, M Estorninho, M Gomez, MC Blokpoel, ND Rawlings, O Dussurget, P Carroll, P Carroll, P Gueneau de Novoa, R Manganelli, RM Raju, S Ahlawat, S Barik, S Engels, S Engels, S Mehra, S Russo, ST Cole, T Akopian, T Msadek, T Parish, Tanya Parish, Yoann Personne   +49 more
core   +9 more sources

Expression, Purification and Characterization of a Novel Hybrid Peptide CLP with Excellent Antibacterial Activity

Molecules, 2021
CLP is a novel hybrid peptide derived from CM4, LL37 and TP5, with significantly reduced hemolytic activity and increased antibacterial activity than parental antimicrobial peptides.
Junhao Cheng, Marhaba Ahmat, Henan Guo, Xubiao Wei, Lulu Zhang, Qiang Cheng, Jing Zhang, Junyong Wang, Dayong Si, Yueping Zhang, Rijun Zhang   +10 more
doaj   +1 more source

Involvement of ClpE ATPase in Physiology of Streptococcus mutans

Microbiology Spectrum, 2021
Streptococcus mutans, a dental pathogen, harbors at least three Clp ATPases (ClpC, ClpE, and ClpX) that form complexes with ClpP protease and participate in regulated proteolysis. Among these, the function of ClpE ATPase is poorly understood.
Saswati Biswas, Hemendra Pal Singh Dhaked, Andrew Keightley, Indranil Biswas   +3 more
doaj   +1 more source

Distinctive Types of ATP-dependent Clp Proteases in Cyanobacteria [PDF]

Journal of Biological Chemistry, 2007
Cyanobacteria are the only prokaryotes that perform oxygenic photosynthesis and are thought to be ancestors to plant chloroplasts. Like chloroplasts, cyanobacteria possess a diverse array of proteolytic enzymes, with one of the most prominent being the ATP-dependent Ser-type Clp protease.
Tara M, Stanne, Elena, Pojidaeva, Fredrik I, Andersson, Adrian K, Clarke   +3 more
openaire   +2 more sources

Acinetobacter baumannii Strains Deficient in the Clp Chaperone-Protease Genes Have Reduced Virulence in a Murine Model of Pneumonia

Pathogens, 2021
Acinetobacter baumannii has emerged as a significant opportunistic Gram-negative pathogen and causative agent of nosocomial pneumonia especially in immunocompromised individuals in intensive care units.
J Christian Belisario, Hiu Ham Lee, Harshani Luknauth, Nathan W. Rigel, Luis R. Martinez   +4 more
doaj   +1 more source

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain [PDF]

, 2013
Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the ...
Fischer, Fabian, Hamann, Andrea, Osiewacz, Heinz D., Weil, Andrea   +3 more
core   +1 more source

Control of plastidial metabolism by the Clp protease complex [PDF]

Journal of Experimental Botany, 2018
Plant metabolism is strongly dependent on plastids. Besides hosting the photosynthetic machinery, these endosymbiotic organelles synthesize starch, fatty acids, amino acids, nucleotides, tetrapyrroles, and isoprenoids. Virtually all enzymes involved in plastid-localized metabolic pathways are encoded by the nuclear genome and imported into plastids ...
Manuel Rodriguez-Concepcion, Lucio D’Andrea, Pablo Pulido   +2 more
openaire   +4 more sources

Protective Roles of Cytosolic and Plastidal Proteasomes on Abiotic Stress and Pathogen Invasion

Plants, 2020
Protein malfunction is typically caused by abiotic stressors. To ensure cell survival during conditions of stress, it is important for plant cells to maintain proteins in their respective functional conformation.
Md. Sarafat Ali, Kwang-Hyun Baek
doaj   +1 more source