Results 1 to 10 of about 487 (89)
eLife, 2021 In many bacteria and eukaryotes, replication fork establishment requires the controlled loading of hexameric, ring-shaped helicases around DNA by AAA+(ATPases Associated with various cellular Activities) ATPases.
Neha Puri +5 more
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A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1
Nature Communications, 2023 Bcs1, a homo-heptameric transmembrane AAA-ATPase, facilitates folded Rieske iron-sulfur protein translocation across the inner mitochondrial membrane. Structures in different nucleotide states (ATPγS, ADP, apo) provided conformational snapshots, but the ...
Yangang Pan +4 more
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AAA+ ATPases in Protein Degradation: Structures, Functions and Mechanisms
Biomolecules, 2020 Adenosine triphosphatases (ATPases) associated with a variety of cellular activities (AAA+), the hexameric ring-shaped motor complexes located in all ATP-driven proteolytic machines, are involved in many cellular processes.
Shuwen Zhang, Youdong Mao
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ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP
eLife, 2020 AAA+ proteases perform regulated protein degradation in all kingdoms of life and consist of a hexameric AAA+ unfoldase/translocase in complex with a self-compartmentalized peptidase.
Sora Kim +4 more
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Crystal structure of the ATPase domain of the human AAA+ protein paraplegin/SPG7. [PDF]
PLoS ONE, 2009 Paraplegin is an m-AAA protease of the mitochondrial inner membrane that is linked to hereditary spastic paraplegias. The gene encodes an FtsH-homology protease domain in tandem with an AAA+ homology ATPase domain.
Tobias Karlberg +6 more
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The Multivesicular Bodies (MVBs)-Localized AAA ATPase LRD6-6 Inhibits Immunity and Cell Death Likely through Regulating MVBs-Mediated Vesicular Trafficking in Rice. [PDF]
PLoS Genetics, 2016 Previous studies have shown that multivesicular bodies (MVBs)/endosomes-mediated vesicular trafficking may play key roles in plant immunity and cell death. However, the molecular regulation is poorly understood in rice.
Xiaobo Zhu +22 more
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The ATPase Activity of Escherichia coli Expressed AAA+-ATPase Protein
Bio-Protocol, 2020 ATPases are the enzymes that breakdown ATP to ADP and release inorganic phosphate (Pi). Here we provide a detailed protocol to determine the ATPase activity of a recombinant AAA+-ATPase protein (GENERAL CONTROL NON-REPRESSIBLE-4 [GCN4]) by ...
Amita Kaundal +2 more
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Journal of Biological Research, 2019 Asthenozoospermia is the most frequent sperm motility disorder, but there are other more extreme sperm motility disorders, namely oligo-astheno-teratozoospermia (OAT) and necrozoospermia.
Silvia W. Lestari +3 more
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Cell Reports, 2019 Summary: AAA+ proteins form asymmetric hexameric rings that hydrolyze ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops.
Célia Deville +4 more
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Nature Communications, 2022 Membrane lipid composition is a key factor for bacterial stress adaptation. Here, authors show that ViaA and AAA+ ATPase RavA, alter lipid composition and modulate E. coli aminoglycoside sensitivity.
Jan Felix +15 more
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