A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1 [PDF]
Nature Communications, 2023 Bcs1, a homo-heptameric transmembrane AAA-ATPase, facilitates folded Rieske iron-sulfur protein translocation across the inner mitochondrial membrane. Structures in different nucleotide states (ATPγS, ADP, apo) provided conformational snapshots, but the ...
Yangang Pan +4 more
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TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching [PDF]
eLife, 2015 The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye +5 more
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Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine [PDF]
Nature Communications, 2021 The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into ...
Michael Prattes +10 more
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Structural insights of the p97/VCP AAA+ ATPase: How adapter interactions coordinate diverse cellular functionality. [PDF]
J Biol Chem, 2023 p97/valosin-containing protein is an essential eukaryotic AAA+ ATPase with diverse functions including protein homeostasis, membrane remodeling, and chromatin regulation.
Braxton JR, Southworth DR.
europepmc +2 more sources
Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration. [PDF]
Nature, 2022 The Holliday junction is a key intermediate formed during DNA recombination across all kingdoms of life 1 . In bacteria, the Holliday junction is processed by two homo-hexameric AAA+ ATPase RuvB motors, which assemble together with the RuvA–Holliday ...
Wald J +6 more
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Functional characterization of a DNA-dependent AAA ATPase in a F-cluster mycobacteriophage. [PDF]
Virus Res, 2023 Highlights • Characterization of a DNA-dependent AAA ATPase with putative DNA repair/maintenance/recombination role.• Sequence evaluation predicted AAA_24 and RecA/RadA domain in AAA ATPase.• Non-denaturing gel electrophoresis and TEM indicated the ...
Das R, Bajpai U.
europepmc +2 more sources
Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis. [PDF]
Cells, 2022 The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism.
Judy RM, Sheedy CJ, Gardner BM.
europepmc +2 more sources
The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48. [PDF]
Mol Cell, 2023 The AAA+ ATPase Cdc48 utilizes the cofactor Ufd1/Npl4 to bind and thread polyubiquitinated substrates for their extraction from complexes or membranes and often for subsequent proteasomal degradation.
Williams C +3 more
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Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1. [PDF]
Nat Struct Mol Biol, 2022 The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling maturation factor Rlp24 from pre-60S particles shortly after nuclear export, a strict ...
Prattes M +13 more
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Structural dynamics of AAA + ATPase Drg1 and mechanism of benzo-diazaborine inhibition [PDF]
Nature Communications, 2022 Drg1 is a cytoplasmic AAA + ATPase responsible for releasing Rlp24 during ribosome assembly. Here, the authors show that Drg1 structurally and functionally shares many regulatory features with that of Cdc48/p97, suggesting a unfoldase role for Drg1.
Chengying Ma +3 more
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