Results 21 to 30 of about 234,152 (246)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1 [PDF]

Nature Communications, 2022
Signaling via the mTOR complex 1 (mTORC1) maintains cellular and organismal homeostasis. Here the authors show that the AAA + ATPase Thorase binds mTOR to promote disassembly and inactivation of mTORC1 to fine tune TOR signaling according to amino acid ...
George K. E. Umanah, Leire Abalde-Atristain, Mohammed Repon Khan, Jaba Mitra, Mohamad Aasif Dar, Melissa Chang, Kavya Tangella, Amy McNamara, Samuel Bennett, Rong Chen, Vasudha Aggarwal, Marisol Cortes, Paul F. Worley, Taekjip Ha, Ted M. Dawson, Valina L. Dawson   +15 more
doaj   +2 more sources

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

eLife, 2017
Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1,
Nicole Monroe, Han Han, Peter S Shen, Wesley I Sundquist, Christopher P Hill   +4 more
doaj   +2 more sources

Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

Nature Communications, 2019
RAD51 assembly on single-stranded DNAs is an important step in the homology-dependent repair of DNA damage. Here authors reveal a role for the human RAD51 paralogue, SWSAP1, as a regulator of RAD51 assembly, by antagonizing RAD51 remodeller, FIGNL1 AAA + 
Kenichiro Matsuzaki, Shizuka Kondo, Tatsuya Ishikawa, Akira Shinohara   +3 more
doaj   +2 more sources

Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7

Nature Communications, 2019
Rix7 is a type II AAA-ATPase that is required for the assembly of the large ribosomal subunit. Here the authors present the 4.5 Å cryo-EM structure of the Rix7 homohexamer with a polypeptide fragment bound in its central channel and provide insights into
Yu-Hua Lo, Mack Sobhany, Allen L. Hsu, Brittany L. Ford, Juno M. Krahn, Mario J. Borgnia, Robin E. Stanley   +6 more
doaj   +2 more sources

Molecular Mechanisms Driving and Regulating the AAA+ ATPase VCP/p97, an Important Therapeutic Target for Treating Cancer, Neurological and Infectious Diseases [PDF]

Biomolecules, 2023
p97/VCP, a highly conserved type II ATPase associated with diverse cellular activities (AAA+ ATPase), is an important therapeutic target in the treatment of neurodegenerative diseases and cancer.
Sepideh Valimehr, Ashish Sethi, Manjari Shukla, Sudipta Bhattacharyya, Mohsen Kazemi, Isabelle Rouiller   +5 more
doaj   +2 more sources

The Rice AAA-ATPase OsFIGNL1 Is Essential for Male Meiosis

Frontiers in Plant Science, 2017
Meiosis is crucial in reproduction of plants and ensuring genetic diversity. Although several genes involved in homologous recombination and DNA repair have been reported, their functions in rice (Oryza sativa) male meiosis remain poorly understood. Here,
Peipei Zhang, Peipei Zhang, Yingxin Zhang, Lianping Sun, Sittipun Sinumporn, Zhengfu Yang, Bin Sun, Dandan Xuan, Zihe Li, Ping Yu, Weixun Wu, Kejian Wang, Liyong Cao, Shihua Cheng   +13 more
doaj   +2 more sources

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

Nature Communications, 2018
Pex1 and Pex6 form a heterohexameric Type-2 AAA-ATPase motor whose function in peroxisomal matrix-protein import is still debated. Here, the authors combine structural, biochemical, and cell-biological approaches to show that Pex1/Pex6 is a protein ...
Brooke M. Gardner, Dominic T. Castanzo, Saikat Chowdhury, Goran Stjepanovic, Matthew S. Stefely, James H. Hurley, Gabriel C. Lander, Andreas Martin   +7 more
doaj   +2 more sources

Biochemical studies of P97 AAA ATPase

, 2007
Imperial Users ...
Briggs , Louise Clare, Briggs , Louise Clare   +1 more
core   +2 more sources

The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

eLife, 2021
In many bacteria and eukaryotes, replication fork establishment requires the controlled loading of hexameric, ring-shaped helicases around DNA by AAA+(ATPases Associated with various cellular Activities) ATPases.
Neha Puri, Amy J Fernandez, Valerie L O'Shea Murray, Sarah McMillan, James L Keck, James M Berger   +5 more
doaj   +1 more source

Coding Mutations in Vacuolar Protein-Sorting 4 AAA+ ATPase Endosomal Sorting Complexes Required for Transport Protein Homologs Underlie bc-2 and New bc-4 Gene Conferring Resistance to Bean Common Mosaic Virus in Common Bean

Frontiers in Plant Science, 2021
Bean common mosaic virus (BCMV) is a major disease in common bean (Phaseolus vulgaris L.). Host plant resistance is the most effective strategy to minimize crop damage against BCMV and the related Bean common mosaic necrosis virus (BCMNV).
Alvaro Soler-Garzón, P. McClean, P. Miklas   +2 more
semanticscholar   +1 more source