Results 41 to 50 of about 3,365 (168)
Comprehensive genome-wide identification of rice AAA-ATPase gene family and functional validation of
Plant StressAAA-ATPases (ATPases associated with diverse cellular activities) play critical roles in diverse cellular activities across organisms. However, systematic analysis of this family in rice and its involvement in disease resistance remains limited.
Wei Zhan +7 more
doaj +1 more source
Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins
eLife, 2014 A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries–the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI–is reconstructed by cryo-electron microscopy to 11 Å ...
Hélène Malet +7 more
doaj +1 more source
Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes
Frontiers in Molecular Biosciences, 2017 Protein complexes of the Type II AAA+ (ATPases associated with diverse cellular activities) family are typically hexamers of 80–150 kDa protomers that harbor two AAA+ ATPase domains.
Paul Saffert +2 more
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The Rice AAA-ATPase OsFIGNL1 Is Essential for Male Meiosis [PDF]
Frontiers in Plant Science, 2017 Meiosis is crucial in reproduction of plants and ensuring genetic diversity. Although several genes involved in homologous recombination and DNA repair have been reported, their functions in rice (Oryza sativa) male meiosis remain poorly understood. Here, we isolated and characterized the rice OsFIGNL1 (OsFidgetin-like 1) gene, encoding a conserved AAA-
Peipei Zhang +13 more
openaire +3 more sources
A CDK-regulated chromatin segregase promoting chromosome replication
Nature Communications, 2021 How cells coordinate chromatin dynamics with the cell cycle machinery to promote genome duplication during S phase is still a matter of study. Here the authors reveal by in vitro reconstitution assays that the AAA + -ATPase containing Yta7 protein in S ...
Erika Chacin +11 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2017 ClpX is a member of the Clp/Hsp100 family of ATP-dependent chaperones and partners with ClpP, a compartmentalized protease, to degrade protein substrates bearing specific recognition signals.
Christopher J. LaBreck +4 more
doaj +1 more source
An empirical energy landscape reveals mechanism of proteasome in polypeptide translocation
eLife, 2022 The ring-like ATPase complexes in the AAA+ family perform diverse cellular functions that require coordination between the conformational transitions of their individual ATPase subunits (Erzberger and Berger, 2006; Puchades et al., 2020).
Rui Fang +3 more
doaj +1 more source
Structure of the active form of human origin recognition complex and its ATPase motor module
eLife, 2017 Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.
Ante Tocilj +7 more
doaj +1 more source
Advanced Science, EarlyView.This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang +9 more
wiley +1 more source