Results 61 to 70 of about 234,152 (246)

Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines [PDF]

Journal of Molecular Biology, 2016
Meiotic clade AAA ATPases (ATPases associated with diverse cellular activities), which were initially grouped on the basis of phylogenetic classification of their AAA ATPase cassette, include four relatively well characterized family members, Vps4, spastin, katanin and fidgetin.
Monroe Nicole, Hill Christopher P
openaire   +3 more sources

The role of the N-D1 linker of the N-ethylmaleimide-sensitive factor in the SNARE disassembly. [PDF]

PLoS ONE, 2013
N-ethylmaleimide-sensitive factor (NSF) is a member of the type II AAA+ (ATPase associated with various cellular activities) family. It plays a critical role in intracellular membrane trafficking by disassembling soluble NSF attachment protein receptor ...
Cui-Cui Liu, Shan Sun, Sen-Fang Sui
doaj   +1 more source

The Interplay of Cofactor Interactions and Post-translational Modifications in the Regulation of the AAA+ ATPase p97

Frontiers in Molecular Biosciences, 2017
The hexameric type II AAA ATPase (ATPase associated with various activities) p97 (also referred to as VCP, Cdc48, and Ter94) is critically involved in a variety of cellular activities including pathways such as DNA replication and repair which both ...
P. Hänzelmann, H. Schindelin
semanticscholar   +1 more source

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a prereplicative complex (pre-RC) with an MCM2-7 double hexamer encircling DNA.
A Costa, A Fernández-Cid, Alberto Riera, Alejandra Fernández-Cid, AS Brewster, AY Lyubimov, B Stillman, BA Kelch, BI Khayrutdinov, Bruce Stillman, C Evrin, C Evrin, C Liu, C Santocanale, C Speck, C Speck, Cecile Evrin, Christian Speck, D Remus, D Remus, D Suck, E Arias-Palomo, EF Pettersen, EL Dueber, G Tang, GC Lander, GD Bowman, GD Pintilie, H Li, H Li, Hironori Kawakami, Huilin Li, I Ilves, IN Chesnokov, J Frigola, J Liu, J Sun, JC Randell, Jingchuan Sun, JL Bowers, L Zou, M Gaudier, M O'Donnell, MG Clarey, MG Clarey, ML Baker, ML Bochman, ML Bochman, ML Bochman, PW Lau, R Henderson, RC Heller, RD Klemm, RJ Fletcher, S Chen, S Donovan, S Onesti, S Waga, SE Moyer, SL Forsburg, SP Bell, SP Bell, Stefan A Samel, T Miyata, T Pape, Y Ishimi, Y Kawasaki, YH Kang, Z Chen   +68 more
core   +1 more source

Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader

eLife, 2022
Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ ATPase complexes.
Christl Gaubitz, Xingchen Liu, Joshua Pajak, Nicholas P Stone, Janelle A Hayes, Gabriel Demo, Brian A Kelch   +6 more
doaj   +1 more source

Uncoupling of p97 ATPase activity has a dominant negative effect on protein extraction [PDF]

, 2019
p97 is a highly abundant, homohexameric AAA+ ATPase that performs a variety of essential cellular functions. Characterized as a ubiquitin-selective chaperone, p97 recognizes proteins conjugated to K48-linked polyubiquitin chains and promotes their ...
Long, David T., Rycenga, Halley B., Wolfe, Kelly B., Yeh, Elizabeth S.   +3 more
core   +1 more source

Assembly principles of a unique cage formed by hexameric and decameric E. coli proteins

eLife, 2014
A 3.3 MDa macromolecular cage between two Escherichia coli proteins with seemingly incompatible symmetries–the hexameric AAA+ ATPase RavA and the decameric inducible lysine decarboxylase LdcI–is reconstructed by cryo-electron microscopy to 11 Å ...
Hélène Malet, Kaiyin Liu, Majida El Bakkouri, Sze Wah Samuel Chan, Gregory Effantin, Maria Bacia, Walid A Houry, Irina Gutsche   +7 more
doaj   +1 more source

Mitochondrial AAA‐ATPase Msp1 detects mislocalized tail‐anchored proteins through a dual‐recognition mechanism

EMBO Reports, 2019
The conserved AAA‐ATPase Msp1 is embedded in the outer mitochondrial membrane and removes mislocalized tail‐anchored (TA) proteins upon dysfunction of the guided entry of tail‐anchored (GET) pathway. It remains unclear how Msp1 recognizes its substrates.
Lanlan Li, Jing Zheng, Xi Wu, Hui Jiang
semanticscholar   +1 more source

Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. [PDF]

, 2013
DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein ...
Cao, L, Fei, X, Jiang, N, Kong, X, Larner, J, Mi, J, Qiu, Y, Shen, Y, Sheng, K, Sun, P   +9 more
core   +1 more source

Structure and Function of p97 and Pex1/6 Type II AAA+ Complexes

Frontiers in Molecular Biosciences, 2017
Protein complexes of the Type II AAA+ (ATPases associated with diverse cellular activities) family are typically hexamers of 80–150 kDa protomers that harbor two AAA+ ATPase domains.
Paul Saffert, Cordula Enenkel, Petra Wendler   +2 more
doaj   +1 more source