Results 51 to 60 of about 3,365 (168)
Inter-ring rotations of AAA ATPase p97 revealed by electron cryomicroscopy [PDF]
Open Biology, 2014 The type II AAA+ protein p97 is involved in numerous cellular activities, including endoplasmic reticulum-associated degradation, transcription activation, membrane fusion and cell-cycle control.
Heidi O. Yeung +7 more
doaj +1 more source
A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)
Developmental Dynamics, EarlyView.Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble +2 more
wiley +1 more source
, 2008 application/pdf研究報告書AAAタンパク質の共通のエンジンであるAAA ATPaseの作動原理、すなわちATP加水分解機構、基質タンパク質への作用機構の解明に取り組んだ。AAAプロテアーゼFtsHの変異体の解析から、 ATPaseリングの孔に位置する酸性残基の重要性や基質特異性に関わる残基を明らかにし、FtsHがポリペプチド鎖の内部から分解を開始できることを明らかにした。research ...
98591, 98589, Ogura, Teru, 小椋, 光
core
Aspartic Protease Inhibition Induces Proteomic Remodeling in Paracoccidioides brasiliensis
PROTEOMICS, EarlyView.ABSTRACT Paracoccidioidomycosis (PCM) is a major systemic mycosis in Latin America caused by Paracoccidioides brasiliensis, yet the contribution of aspartic proteases to fungal physiology and pathogenicity remains poorly understood. Here, we employed data‐independent acquisition (DIA)‐based quantitative proteomics to investigate the impact of pepstatin
Sarah Fernandes Lima +6 more
wiley +1 more source
Structure of the central Staphylococcus aureus AAA+ protease MecA/ClpC/ClpP
Communications BiologyBacterial AAA+ proteases are composed of a AAA+ partner (e.g., ClpC) and an associated peptidase (e.g., ClpP). They represent ATP-fuelled and self-compartmentalized proteolytic machines that are crucial for stress resistance and virulence.
Stavros Azinas +6 more
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder +7 more
wiley +1 more source
The AAA + ATPase Thorase is neuroprotective against ischemic injury [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2018 Neuronal preconditioning in vitro or in vivo with a stressful but non-lethal stimulus leads to new protein expression that mediates a profound neuroprotection against glutamate excitotoxicity and experimental stroke. The proteins that mediate neuroprotection are relatively unknown and under discovery.
Jianmin Zhang +13 more
openaire +2 more sources
A novel growth-related AAA ATPase from plants
, 1999 The process of cell enlargement whereby cells enlarge following cytokinesis has been little studied. The purpose of this thesis was to develop a cell-free assay which would facilitate the study of this phenomenon and to identify involved genes and gene ...
Hicks, Carrie Allison
core +1 more source
The FEBS Journal, EarlyView.As we age, cells gradually accumulate damage, which can contribute to disease and neurodegeneration. This review explores how two cellular recycling processes, mitophagy and nucleophagy, remove damaged mitochondria and nuclear material, respectively, to maintain cell health and long‐term neuronal homeostasis.
Maria Markaki, Nektarios Tavernarakis
wiley +1 more source
The FEBS Journal, EarlyView.Lipid droplets (LD) act as cellular ‘garbage trucks’ that transport cytosolic protein aggregates to the vacuole for degradation in yeast. Protein aggregates are docked to lipid droplets in a triacylglycerol‐dependent manner, transported through the cytoplasm, and transferred to the insoluble protein deposit (IPOD) at the vacuole.
Christoph Reiter +15 more
wiley +1 more source