Results 71 to 80 of about 3,365 (168)

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

eLife, 2015
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved HORMA domain family.
Qiaozhen Ye, Scott C Rosenberg, Arne Moeller, Jeffrey A Speir, Tiffany Y Su, Kevin D Corbett   +5 more
doaj   +1 more source

Targeted Mutagenesis Reveals Noncanonical Genetic Requirements for Carbon Monoxide Oxidation

Environmental Microbiology, Volume 28, Issue 11, November 2026.
Using targeted mutagenesis, this study shows that form II CODH does not contribute to CO oxidation in the model carboxydovore Paraburkholderia terrae COX and reveals that canonical maturation pathways are not universally conserved. These findings refine genome‐based predictions of microbial metabolism and improve understanding of metalloenzyme assembly
R. A. Dawson, M. Hernández
wiley   +1 more source

Insights into the Structure and Function of the Pex1/Pex6 AAA-ATPase in Peroxisome Homeostasis [PDF]

, 2022
The AAA-ATPases Pex1 and Pex6 are required for the formation and maintenance of peroxisomes, membrane-bound organelles that harbor enzymes for specialized metabolism.
Sheedy, Connor J., Judy, Ryan M., Judy, Ryan M, Connor J. Sheedy, Sheedy, Connor J, Ryan M. Judy, Gardner, Brooke M, Gardner, Brooke M., Brooke M. Gardner   +8 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, Volume 600, Issue 19, Page 2917-2928, October 2026.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Characterization of arc, a divergent member of the aaa atpase family from rhodococcus erythropolis

, 1998
A gene encoding a AAA ATPase was discovered in the 5' region of the second operon of 20 S proteasome subunits in the nocardioform actinomycete Rhodococcus erythropolis NI86/21. The gene was cloned and expressed in Escherichia coli.
Cejka, Z., Pfeifer, G., Engel, A., Lupas, A. ; https://orcid.org/, Müller, S., Wolf, S., Nagy, I., Baumeister, W., Demot, R.   +8 more
core   +1 more source

Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4 [PDF]

Biochemical Society Transactions, 2019
Abstract The progression of ESCRT (Endosomal Sorting Complexes Required for Transport) pathways, which mediate numerous cellular membrane fission events, is driven by the enzyme Vps4. Understanding of Vps4 mechanism is, therefore, of fundamental importance in its own right and, moreover, it is highly relevant to the understanding of many
Han Han, Christopher P. Hill
openaire   +2 more sources

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2002-2016, October 2026.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Dataset for: The AAA protein spastin possesses two levels of basal ATPase activity.

, 2018
The AAA ATPase spastin is a microtubule-severing enzyme that plays important roles in various cellular events including axon regeneration. Herein, we found that the basal ATPase activity of spastin is negatively regulated by spastin concentration.
Gulijiazi Habai (5135324), Maorong Wen (5135312), Linyue Sun (5135297), Pengpeng Yu (5135309), Yuequan Shen (5135306), Jing Lu (5135315), Xiangyu Fan (5135303), Zhijie Lin (5135300), Chunguang Wang (5135294), Guanghui Fan (5135321), Yongfei Hou (5135318)   +10 more
core   +1 more source

Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway

, 2023
Abstract The Cdc48 AAA+ ATPase is an abundant and essential enzyme that unfolds substrates in multiple protein quality control pathways. The enzyme includes two conserved AAA+ ATPase cassettes, D1 and D2, that assemble as hexameric rings with D1 stacked above D2.
Ian Cooney, Heidi L. Schubert, Karina Cedeno, Hsien-Jung L. Lin, John C Price, Christopher P Hill, Peter S Shen   +6 more
openaire   +2 more sources

Proteomic Analysis of Three Independent Series of Sequential Cystic Fibrosis Strains in an International Pseudomonas aeruginosa Reference Panel Indicates Positive Selection in Late Infection Strains

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Comparison of proteomes from three series of sequential Pseudomonas aeruginosa isolates from people with cystic fibrosis identified eleven proteins with increased abundance in at least one late isolate per patient. Three proteins were increased in all five late isolates, and the probability of this occurring by chance is 5.06 × 10−53, indicating strong
Joanna Drabinska, Lucia O'Connor, Caoilin McClean, Siobhán McClean   +3 more
wiley   +1 more source