Results 91 to 100 of about 3,365 (168)

Analysis of endocytosis at eisosomes [PDF]

, 2011
The yeast plasma membrane contains at least three microdomains – membrane compartment containing Pma1 (MCP), membrane compartment containing TORC2 (MCT) and membrane compartment containing Can1 (MCC).
Rehman, Michael
core   +1 more source

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

eLife, 2017
Many important cellular membrane fission reactions are driven by ESCRT pathways, which culminate in disassembly of ESCRT-III polymers by the AAA ATPase Vps4. We report a 4.3 Å resolution cryo-EM structure of the active Vps4 hexamer with its cofactor Vta1,
Nicole Monroe, Han Han, Peter S Shen, Wesley I Sundquist, Christopher P Hill   +4 more
doaj   +1 more source

Phenotypic Exploration in Patients with Heterozygous Variant in AFG3L2 Gene: A Case‐Series and Literature Review

Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2250-2258, September 2026.
Abstract Background Variants in AFG3‐Like Matrix AAA Peptidase, Subunit 2 (AFG3L2) gene are associated with diverse clinical phenotypes. Here, we describe phenotypic findings of two unrelated children with de novo heterozygous variant and one family with inherited heterozygous variant in AFG3L2 gene.
Sangeetha Yoganathan, Laura Tochen, Jacky Ganguly, Sayoni Roy Chowdhury, Haya S AlFaris, Vivek Pai, Andrea LeBlanc‐Millar, Sara Breitbart, Hrishikesh Kumar, Manohar Shroff, Arun Reginald, Grace Yoon, Alfonso Fasano, George M Ibrahim, Carolina Gorodetsky   +14 more
wiley   +1 more source

The Pvc15 ATPase selectively associates effector proteins with the Photorhabdus virulence cassette

Royal Society Open Science
The Photorhabdus virulence cassette (PVC) is an extracellular contractile injection system. In the producing bacterium, N-terminal signal peptides enable effector ‘payloads’ to be loaded into the PVC’s hollow tube—facilitated by the ‘ATPases associated ...
Rhys Evans, Nicholas R. Waterfield
doaj   +1 more source

Predicting the Toxicity of Chemical Compounds via Hyperdimensional Computing

Molecular Informatics, Volume 45, Issue 9, September 2026.
Hyperdimensional computing converts text representations of chemical structures (SMILES) into high‐dimensional vectors. New compounds are classified by comparison with learned toxic and nontoxic reference patterns; across 12 Tox21 targets, overlapping four‐character SMILES patterns performed best among tested representations, supporting fast ...
Fabio Cumbo, Kabir Dhillon, Jayadev Joshi, Bryan Raubenolt, Davide Chicco, Sercan Aygun, Daniel Blankenberg   +6 more
wiley   +1 more source

The AAA+ ATPases and HflB/FtsH Proteases of ‘Candidatus Phytoplasma mali’: Phylogenetic Diversity, Membrane Topology, and Relationship to Strain Virulence

Molecular Plant-Microbe Interactions, 2013
Previous examination revealed a correlation of phytopathogenic data of ‘Candidatus Phytoplasma mali’ strains and the DNA sequence variability of a type ATP00464 hflB gene fragment. To further investigate such a relationship, all distinct genes previously
Erich Seemüller, Sandor Sule, Michael Kube, Wilhelm Jelkmann, Bernd Schneider   +4 more
doaj   +1 more source

Comprehensive Investigation of Benzimidazolium Derivatives Through Synthesis, Characterization, Cytotoxicity Activity, Immunocytochemistry, and ADME and Toxicity Analyses

ChemistryOpen, Volume 15, Issue 9, September 2026.
Three benzimidazolium derivatives bearing fluoro, chloro, and methoxy substituents are synthesized and evaluated for anticancer activity. Compound 2b shows the highest antiproliferative activity and induces apoptosis through caspase‐3 activation and PARP1 cleavage. In this study, three novel benzimidazolium derivatives (2a–c) bearing 4‐fluoro, 3‐chloro,
Gulay Dilek, Senem Akkoc
wiley   +1 more source

The Vps4 C-terminal helix is a critical determinant for assembly and ATPase activity and has elements conserved in other members of the meiotic clade of AAA ATPases. [PDF]

, 2008
Sorting of membrane proteins into intralumenal endosomal vesicles, multivesicular body (MVB) sorting, is critical for receptor down regulation, antigen presentation and enveloped virus budding.
Munn, A. L., Gan, A. L., Landsberg, Michael J, Munn, Alan L, Parimala R. Vajjhala, Nguyen, Chau H, Hankamer, B., King, G. F., Nguyen , C. H., Hankamer, Ben, Kistler, C., Michael J. Landsberg, Alan L. Munn, Kistler, Carol, Carol Kistler, Vajjhala, P. R., Vajjhala, Parimala R, Ai‐Lin Gan, Glenn F. King, Gan, Ai-Lin, King, Glenn F, Chau H. Nguyen, Landsberg, M. J., Ben Hankamer   +23 more
core   +1 more source

A novel AAA+ ATPase required for sporulation and stress response in Bacillus anthracis

Journal of Bacteriology
AAA+ proteins function as molecular machines that utilize ATP to perform diverse cellular functions, including protein homeostasis, stress regulation, and cell cycle/developmental processes.
Nitika Sangwan, Ankur Bothra, Andrei P. Pomerantsev, Aakriti Gangwal, Rasem Fattah, Mahtab Moayeri, Qian Ma, Sundar Ganesan, Chetkar Chandra Keshavam, Renu Baweja, Uma Dhawan, Stephen H. Leppla, Yogendra Singh   +12 more
doaj   +1 more source

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers

Nature Communications, 2016
The AAA+ ATPase p97 is an essential hexameric protein with multiple protein interaction partners and cellular functions. Here, the authors use interaction mapping to examine partner proteins of this large complex, and assess the effects of these proteins
Anup Arumughan, Yvette Roske, Carolin Barth, Laura Lleras Forero, Kenny Bravo-Rodriguez, Alexandra Redel, Simona Kostova, Erik McShane, Robert Opitz, Katja Faelber, Kirstin Rau, Thorsten Mielke, Oliver Daumke, Matthias Selbach, Elsa Sanchez-Garcia, Oliver Rocks, Daniela Panáková, Udo Heinemann, Erich E. Wanker   +18 more
doaj   +1 more source