Results 101 to 110 of about 234,152 (246)

The Oligomeric State of the Active Vps4 AAA ATPase [PDF]

Journal of Molecular Biology, 2014
The cellular ESCRT (endosomal sorting complexes required for transport) pathway drives membrane constriction toward the cytosol and effects membrane fission during cytokinesis, endosomal sorting, and the release of many enveloped viruses, including the human immunodeficiency virus.
Monroe Nicole, Han Han, Gonciarz Malgorzata D, Eckert Debra M, Karren Mary Anne, Whitby Frank G, Sundquist Wesley I, Hill Christopher P   +7 more
openaire   +3 more sources

Mutant mitochondrial elongation factor G1 and combined oxidative phosphorylation deficiency [PDF]

, 2004
Although most components of the mitochondrial translation apparatus are encoded by nuclear genes, all known molecular defects associated with impaired mitochondrial translation are due to mutations in mitochondrial DNA.
Antonicka, H, Coenen, MJH, Heister, A, Newbold, RF, Rossi, R, Sasarman, F, Shoubridge, EA, Smeitink, JAM, Trijbels, FJMF, Ugalde, C, van den Heuvel, LP   +10 more
core   +9 more sources

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization [PDF]

, 2013
The origin recognition complex (ORC) of Saccharomyces cerevisiae binds origin DNA and cooperates with Cdc6 and Cdt1 to load the replicative helicase MCM2–7 onto DNA. Helicase loading involves two MCM2–7 hexamers that assemble into a double hexamer around
A. Fernandez-Cid, A. Riera, Bell, Bowers, Bray, C. Evrin, C. Speck, Casas-Terradellas, Chen, Cocker, Coleman, Costa, Donovan, Dueber, Gillespie, Herbig, Holm, J. Zech, Klemm, Krupinski, Laemmli, Liang, Liang, Liu, M. C. Herrera, Mizushima, Neuwald, P. Clarke, Perkins, R. Lurz, Randell, Remus, Remus, Roy, S. Brill, Schepers, Seki, Singleton, Steven, Stoeber, Takara, Tanaka, Watanabe, Weinreich, Wendler, Williams, Ying, Zhang   +47 more
core   +1 more source

The ZmCOP1s–ZmCOL3 Module Enhances Late Flowering, Grain Yield and Grain Quality in Maize

Plant Biotechnology Journal, EarlyView.
ABSTRACT Flowering time is a key determinant of yield and regional adaptation in crops and is largely controlled by light signalling. In this study, we identified two maize orthologs of Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1), designated ZmCOP1a and ZmCOP1b, which activate light signalling and reduce plant height. Loss‐of‐function mutants of
Shuling Yang, Yanpei Zhang, Lianhua Cui, Weimin Zhan, Shizhan Chen, Yu Zhang, Haolei Han, Linhu Song, Longchao Du, Kangni Zhang, Huan Liu, Shaoci Wang, Yong Shi, Jihua Tang, Xiangguo Liu, Jianping Yang   +15 more
wiley   +1 more source

Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication

eLife, 2016
Replisome assembly requires the loading of replicative hexameric helicases onto origins by AAA+ ATPases. How loader activity is appropriately controlled remains unclear.
Iris V Hood, James M Berger
doaj   +1 more source

VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. [PDF]

, 2015
Lysosomes are classically viewed as vesicular structures to which cargos are delivered for degradation. Here, we identify a network of dynamic, tubular lysosomes that extends throughout Drosophila muscle, in vivo. Live imaging reveals that autophagosomes
Davis, Graeme W, Hauswirth, Anna G, Johnson, Alyssa E, Shu, Huidy, Tong, Amy   +4 more
core   +3 more sources

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Arabidopsis mutants reveal multiple singlet oxygen signaling pathways involved in stress response and development [PDF]

, 2018
Shortly after the release of singlet oxygen (1O2) in chloroplasts drastic changes in nuclear gene expression occur in the conditional flu mutant of Arabidopsis that reveal a rapid transfer of signals from the plastid to the nucleus.
Apel, Klaus, Baruah, Aiswarya, Laloi, Christophe, Šimková, Klára   +3 more
core  

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Proteolytic control of mitochondrial protein translocases

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondria are essential organelles that drive numerous cellular processes, including energy metabolism, ion homeostasis, and programmed cell death. This functional versatility relies on a highly dynamic proteome whose composition is continuously remodeled to meet changing cellular and environmental demands.
Lara Kroczek, Thomas Langer
wiley   +1 more source