Results 121 to 130 of about 234,152 (246)

Role of the ubiquitin-selective CDC-48/UFD-1/NPL-4 chaperone in DNA replication [PDF]

, 2012
Faithful transmission of genomic information requires tight spatiotemporal regulation of DNA replication factors. Posttranslational modifications, such as ubiquitylation, constitute a fast and effective mechanism to control such complex protein function.
Franz, André
core  

Model for the unidirectional motion of a dynein molecule

, 2008
Cytoplasmic dyneins transport cellular organelles by moving on a microtubule filament. It has been found recently that depending on the applied force and the concentration of the adenosine triphosphate (ATP) molecules, dynein's step size varies. Based on
B. Alberts, M. Schnitzer, S. M. King, Sutapa Mukherji, T. Shima   +4 more
core   +1 more source

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae

Advanced Science, Volume 13, Issue 24, 27 April 2026.
MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia, Yunna Zheng, Nan Yang, Jing Chen, Xi Wu, Ximing Zheng, Danrui Cui, Ruijin Wang, Xunli Lu, Dongli Wang, You‐liang Peng, Qian Chen   +11 more
wiley   +1 more source

Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis

Frontiers in Molecular Biosciences, 2020
TorsinA is a AAA+ ATPase involved in the severe neurological disease Early Onset Torsion Dystonia. Despite the impressive progress in the field in the recent years, the structural organization and function of this intriguing molecule is still not clear ...
Christian Fercher, Lucía F. Zacchi
doaj   +1 more source

Bioactivity Profiling of Coronarin A and Villosin Isolated From Hedychium coronarium J. Koenig: Acaricidal, Nematicidal, and Antifungal Potential

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
The graphical abstract illustrates the flowchart for the isolation and evaluation of bioactive compounds from Hedychium coronarium. Crude extracts were obtained via cold percolation from the aerial parts (flowers, leaves, and stems) using dichloromethane (DCM) and from the rhizomes using chloroform.
Riddhiman Lahiri, Ravendra Kumar, Sushila Arya, Alok Pratap Singh, Sakshi Negi, Shivang Joshi, Pooja Bargali, Suraj N. Mali, Shilpi Rawat, Mozaniel Santana de Oliveira, Prahlad Sarkar   +10 more
wiley   +1 more source

Modifying Effect of the Antibiotic Action, Membrane Permeability, and ADMET/Toxicity Profile of the Fixed Oil From the Pulp of Mauritia Flexuosa F.L. (Arecaceae)

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT The increasing bacterial resistance to antibiotics has stimulated the search for natural products capable of modulating antimicrobial activity. In this study, the fixed oil from Mauritia flexuosa pulp was evaluated for its antibacterial activity, modulatory effect on antibiotics, membrane permeability, and ADMET/toxicity profile.
Isaac Moura Araújo, Cleidiana Tomé de Oliveira, Luís Pereira‐de‐Morais, Andressa Silva Alencar, Cicera Datiane de Morais Oliveira‐Tintino, Maria Alícia Cavalcante Narciso, Anita Oliveira Brito Pereira Bezerra Martins, Sara Tavares de Sousa Machado, Sheila Alves Gonçalves, Daniel Sampaio Alves, Janaina Esmeraldo Rocha, Ana Carolina Ferreira Araújo, Priscilla Ramos Freitas, José Weverton Almeida‐Bezerra, José Thyálisson da Costa Silva, Henrique Douglas Melo Coutinho   +15 more
wiley   +1 more source

The Pvc15 ATPase selectively associates effector proteins with the Photorhabdus virulence cassette

Royal Society Open Science
The Photorhabdus virulence cassette (PVC) is an extracellular contractile injection system. In the producing bacterium, N-terminal signal peptides enable effector ‘payloads’ to be loaded into the PVC’s hollow tube—facilitated by the ‘ATPases associated ...
Rhys Evans, Nicholas R. Waterfield
doaj   +1 more source

A Perspective on the Enhancer Dependent Bacterial RNA Polymerase

Biomolecules, 2015
Here we review recent findings and offer a perspective on how the major variant RNA polymerase of bacteria, which contains the sigma54 factor, functions for regulated gene expression.
Nan Zhang, Martin Buck
doaj   +1 more source

Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97

ACS Medicinal Chemistry Letters, 2018
Optimization of the side-chain of a phenyl indole scaffold identified from a high-throughput screening campaign for inhibitors of the AAA+ ATPase p97 is reported.
M. Laporte, J. Burnett, R. Colombo, Stacie L. Bulfer, Celeste N Alverez, T. Chou, R. J. Neitz, Neal Green, William J. Moore, Zhizhou Yue, Shan Li, M. Arkin, P. Wipf, D. Huryn   +13 more
semanticscholar   +1 more source

Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. [PDF]

, 2019
Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-synuclein implicated in fatal neurodegenerative disorders. Problematically,
Carman, Peter J, Gambogi, Craig, Gates, Stephanie N, Gurpinar, Esin, Hernandez Murillo, Oscar A, Hesketh, Christina D, Jackrel, Meredith E, Lin, JiaBei, Mack, Korrie L, Rizo, Alexandra N, Shorter, James, Southworth, Daniel R, Stillman, Jacob, Sudesh, Saurabh, Sweeny, Elizabeth A, Tariq, Amber, Weitzman, Rachel, Yee, Keolamau, Yokom, Adam L   +18 more
core   +1 more source