Results 111 to 120 of about 234,152 (246)

Conformational changes in the AAA ATPase p97–p47 adaptor complex [PDF]

The EMBO Journal, 2006
The AAA+ATPase p97/VCP, helped by adaptor proteins, exerts its essential role in cellular events such as endoplasmic reticulum-associated protein degradation or the reassembly of Golgi, ER and the nuclear envelope after mitosis. Here, we report the three-dimensional cryo-electron microscopy structures at approximately 20 Angstroms resolution in two ...
Beuron, Fabienne, Dreveny, Ingrid, Yuan, Xuemei, Pye, Valerie E., Mckeown, Ciaran, Briggs, Louise C., Cliff, Matthew J., Kaneko, Yayoi, Wallis, Russell, Isaacson, Rivka L., Ladbury, John E., Matthews, Steve J., Kondo, Hisao, Zhang, Xiaodong, Freemont, Paul S.   +14 more
openaire   +4 more sources

Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4

Biochemical Society Transactions, 2019
The progression of ESCRT (Endosomal Sorting Complexes Required for Transport) pathways, which mediate numerous cellular membrane fission events, is driven by the enzyme Vps4. Understanding of Vps4 mechanism is, therefore, of fundamental importance in its
H. Han, C. Hill
semanticscholar   +1 more source

Quality control of protein import into mammalian mitochondria

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein, Laurie Lee‐Glover, Hilla Weidberg   +2 more
wiley   +1 more source

Origin and Functional Evolution of the Cdc48/p97/VCP AAA+ Protein Unfolding and Remodeling Machine [PDF]

, 2018
The AAA + Cdc48 ATPase (alias p97 or VCP) is a key player in multiple ubiquitin-dependent cell signaling, degradation, and quality control pathways. Central to these broad biological functions is the ability of Cdc48 to interact with a large number of ...
Barthelme, Dominik, Sauer, Robert T.
core   +1 more source

Beneficial rhizobacteria and virus infection modulate the soybean metabolome and influence the feeding preferences of the virus vector Epilachna varivestis

New Phytologist, Volume 250, Issue 4, Page 2599-2618, May 2026.
Summary Beneficial rhizobacteria and viral pathogens can both alter host plant phenotypes, yet little is known about how their simultaneous presence influences plant metabolism and species interactions. We investigated how two rhizobacteria, Bradyrhizobium japonicum and Delftia acidovorans, together with bean pod mottle virus (BPMV), shape soybean ...
Hannier Pulido, Kerry E. Mauck, Consuelo M. De Moraes, Mark C. Mescher   +3 more
wiley   +1 more source

Dynamic functional assembly of the Torsin AAA+ ATPase and its modulation by LAP1

Molecular Biology of the Cell, 2017
TorsinA is an essential AAA+ ATPase requiring LAP1 or LULL1 as cofactors. The dynamics of the Torsin/cofactor system remain poorly understood, with previous models invoking Torsin/cofactor assemblies with fixed stoichiometries.
A. Chase, Ethan Laudermilch, Jimin Wang, H. Shigematsu, T. Yokoyama, Christian Schlieker   +5 more
semanticscholar   +1 more source

Model for eukaryotic tail-anchored protein binding based on the structure of Get3 [PDF]

, 2009
The Get3 ATPase directs the delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). TA-proteins are characterized by having a single transmembrane helix (TM) at their extreme C terminus and include many essential proteins, such as ...
Ahmadian, Borgese, Boskovic, C. J. M. Suloway, Ching, Freymann, Georgiadis, Halic, Hann, Hemmingsson, J. W. Chartron, Jonikas, Kao, Koonin, Kutay, Lukasik, Lutkenhaus, M. Zaslaver, Milburn, Montoya, Netz, Ogura, Scheffzek, Schindelin, Schlessman, Schuldiner, Schuldiner, Shen, Sprang, Stefanovic, Tseng, W. M. Clemons, Wang, Zhou, Z    iga   +34 more
core   +3 more sources

CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Ferroptosis is driven by mitochondrial permeability transition pore (mPTP) opening, which induces mitochondrial swelling and releases oxidized mitochondrial DNA. The released mtDNA activates cGAS–STING signaling, promotes ferritinophagy, and amplifies ferroptotic cell death. Disruption of mtDNA repair sensitizes tumors to ferroptosis in vivo, revealing
Hong Zhou, Wan Fu, Shizuo Liu, Zili Zhang, Hanyan Luo, Qing Zhong   +5 more
wiley   +1 more source

Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway

, 2023
AbstractThe Cdc48 AAA+ ATPase is an abundant and essential enzyme that unfolds substrates in multiple protein quality control pathways. The enzyme includes two conserved AAA+ ATPase cassettes, D1 and D2, that assemble as hexameric rings with D1 stacked above D2. Here, we report an ensemble of structures of Cdc48 affinity purified from lysate in complex
Ian Cooney, Heidi L. Schubert, Karina Cedeno, Hsien-Jung L. Lin, John C Price, Christopher P Hill, Peter S Shen   +6 more
openaire   +2 more sources

Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Life depends on the ability of organisms such as plants to convert the gas carbon dioxide into sugar molecules to produce energy and build biomass. Most of this activity is catalyzed by the CO2-fixing enzyme Rubisco.
Y. Tsai, F. Ye, L. Liew, Di Liu, S. Bhushan, Yonggui Gao, O. Mueller-Cajar   +6 more
semanticscholar   +1 more source