Results 81 to 90 of about 3,365 (168)

The Role of the N-Domain in the ATPase Activity of the Mammalian AAA ATPase p97/VCP [PDF]

Journal of Biological Chemistry, 2012
p97/valosin-containing protein (VCP) is a type II ATPase associated with various cellular activities that forms a homohexamer with each protomer containing an N-terminal domain (N-domain); two ATPase domains, D1 and D2; and a disordered C-terminal region.
Niwa, Hajime, Ewens, Caroline A., Tsang, Chun, Yeung, Heidi O., Zhang, Xiaodong, Freemont, Paul S.   +5 more
openaire   +2 more sources

AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy

Nature Communications
Peroxisomes are organelles that are central to lipid metabolism and chemical detoxification. Despite advances in our understanding of peroxisome biogenesis, the mechanisms maintaining peroxisomal membrane proteins remain to be fully elucidated.
Fumika Koyano, Koji Yamano, Tomoyuki Hoshina, Hidetaka Kosako, Yukio Fujiki, Keiji Tanaka, Noriyuki Matsuda   +6 more
doaj   +1 more source

SPG4 Hereditary Spastic Paraplegia: From Etiology to Therapy

Movement Disorders, Volume 41, Issue 10, Page 2592-2605, October 2026.
Abstract Hereditary spastic paraplegias (HSPs) comprise a heterogeneous group of heritable neurodegenerative disorders resulting from mutations in a wide variety of genes. HSP locomotor symptoms include lower limb weakness and spasticity that arise from progressive degeneration of corticospinal axons projecting from the motor cortex to the distal ...
Emanuela Piermarini, Peter W. Baas
wiley   +1 more source

The 'glutamate switch' provides a link between ATPase activity and ligand binding in AAA plus proteins

, 2008
AAA+ proteins carry out diverse functions in cells. In most cases, their ATPase activity is tightly regulated by protein partners and target ligands, but the mechanism for this control has remained unclear. We have identified a conserved link between the
Dale B Wigley, Zhang, Xiaodong, Wigley, Dale B, Xiaodong Zhang   +3 more
core   +1 more source

Role of AAA-ATPase Cdc48p in peroxisomal quality control [PDF]

Cell Reports
Most peroxisomal matrix proteins contain a type 1 peroxisomal targeting signal (PTS1), which is recognized by the cytosolic receptor Pex5p for delivery into peroxisomes. Following cargo translocation, the receptor is monoubiquitinated and recycled to the cytosol by the AAA-ATPases Pex1p and Pex6p.
Ismaila Francis Yusuf, Tomasz Jeziorek, Andrea Droste, Wolfgang Girzalsky, Ralf Erdmann   +4 more
openaire   +2 more sources

A Perspective on the Enhancer Dependent Bacterial RNA Polymerase

Biomolecules, 2015
Here we review recent findings and offer a perspective on how the major variant RNA polymerase of bacteria, which contains the sigma54 factor, functions for regulated gene expression.
Nan Zhang, Martin Buck
doaj   +1 more source

Resolving the TorsinA Oligomerization Conundrum: The Glycan Hypothesis

Frontiers in Molecular Biosciences, 2020
TorsinA is a AAA+ ATPase involved in the severe neurological disease Early Onset Torsion Dystonia. Despite the impressive progress in the field in the recent years, the structural organization and function of this intriguing molecule is still not clear ...
Christian Fercher, Lucía F. Zacchi
doaj   +1 more source

Genomic Signatures of Endemic Pathogen Exposure in a Declining Amphibian

Molecular Ecology, Volume 35, Issue 20, October 2026.
ABSTRACT Endemic wildlife diseases can impose strong selection on threatened populations, yet whether persistence is associated with adaptive genomic responses remains poorly understood. We tested whether long‐term exposure to Batrachochytrium dendrobatidis (Bd) following population declines has left detectable selection signatures in the genome of the
Alexander S. Wendt, Lee Berger, Lee F. Skerratt, Laura A. Brannelly   +3 more
wiley   +1 more source

Human RAD51 paralogue SWSAP1 fosters RAD51 filament by regulating the anti-recombinase FIGNL1 AAA+ ATPase

Nature Communications, 2019
RAD51 assembly on single-stranded DNAs is an important step in the homology-dependent repair of DNA damage. Here authors reveal a role for the human RAD51 paralogue, SWSAP1, as a regulator of RAD51 assembly, by antagonizing RAD51 remodeller, FIGNL1 AAA + 
Kenichiro Matsuzaki, Shizuka Kondo, Tatsuya Ishikawa, Akira Shinohara   +3 more
doaj   +1 more source

Extrusion Bioprinting for Wound Healing: Innovations in Functionalized Bioinks and Bioprinting Technology

Advanced Materials Technologies, Volume 11, Issue 18, 18 September 2026.
Extrusion‐based bioprinting (EBB) has emerged as a versatile biofabrication platform capable of precisely depositing bioinks composed of biomaterials, cells, and bioactive agents to generate patient‐specific, biomimetic skin constructs. This paper presents a state‐of‐the‐art and forward‐looking overview of EBB for wound healing, encompassing printing ...
Hien‐Phuong Le, Anh Tuan Trong Tran, Ammara Waheed, Tran Thanh Tung, Dusan Losic   +4 more
wiley   +1 more source