Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease [PDF]
, 2009 Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M.
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Veterinary Research, 2023 The process of intracellular proteolysis through ATP-dependent proteases is a biologically conserved phenomenon. The stress responses and bacterial virulence of various pathogenic bacteria are associated with the ATP-dependent Clp protease. In this study,
Dongjie Sun +11 more
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Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis
mBio, 2023 Bacterial AAA+ unfoldases are crucial for bacterial physiology by recognizing specific substrates and, typically, unfolding them for degradation by a proteolytic component. The caseinolytic protease (Clp) system is one example where a hexameric unfoldase
Stefan Pan +7 more
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Extreme variation in rates of evolution in the plastid Clp protease complex [PDF]
The Plant Journal, 2018 Abstract Eukaryotic cells represent an intricate collaboration between multiple genomes, even down to the level of multisubunit complexes in mitochondria and plastids. One such complex in plants is the caseinolytic protease (Clp), which plays an essential role in plastid protein turnover.
Alissa M. Williams +3 more
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Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP
mBio, 2020 Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates.
Nadine Silber +5 more
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Structural and functional insights into the chloroplast ATP-dependent Clp protease in Arabidopsis [PDF]
, 2006 In contrast with the model Escherichia coli Clp protease, the ATP-dependent Clp protease in higher plants has a remarkably diverse proteolytic core consisting of multiple ClpP and ClpR paralogs, presumably arranged within a dual heptameric ring structure.
Tara M. Stanne +17 more
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Biochemical studies of the essential Clp protease in cyanobacteria and its associated adaptor proteins [PDF]
, 2014 Proteins are an essential part of all organisms and are involved in many cellular processes. To regulate the function of proteins and facilitate their removal when damaged or otherwise compromised, sophisticated control systems have evolved that include ...
Tryggvesson, Anders
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Cross genome comparisons of serine proteases in Arabidopsis and rice
BMC Genomics, 2006 Background Serine proteases are one of the largest groups of proteolytic enzymes found across all kingdoms of life and are associated with several essential physiological pathways.
Sowdhamini R, Tripathi Lokesh P
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Pyrazinamide triggers degradation of its target aspartate decarboxylase
Nature Communications, 2020 It has been shown that the bioactive component of pyrazinamide, pyrazinoic acid (POA), blocks coenzyme A biosynthesis in M. tuberculosis by binding to the aspartate decarboxylase PanD.
Pooja Gopal +14 more
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Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice. [PDF]
PLoS ONE, 2016 Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by cecal ligation and puncture (CLP) suggested that the protease factor XIa contributed to ...
Charles E Bane +10 more
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