Results 61 to 70 of about 17,783 (200)

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Protein purification to analyze AAA+ proteolytic machine in vitro [PDF]

, 2011
The ATP-dependent ClpXP protease of Escherichia coli consists of two subunits, the ClpP subunit, which has the proteolytic activity and the AAA+ motor ClpX, which mechanically unfolds and translocates substrates for ClpP degradation.
Rojas, Diego F.
core   +2 more sources

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition [PDF]

, 2016
M. tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding
Barry III, CE, Brandenburg, J, Prosser, G, Reiling, N, Wilkinson, KA, Wilkinson, RJ   +5 more
core   +1 more source

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. [PDF]

, 2020
Mammalian circadian rhythms are generated by a transcription-based feedback loop in which CLOCK:BMAL1 drives transcription of its repressors (PER1/2, CRY1/2), which ultimately interact with CLOCK:BMAL1 to close the feedback loop with ~24 hr periodicity ...
Abraham, Adams, Anand, Aryal, Battye, Beckett, Berendsen, Brautigam, Bussi, Czarna, Czarna, Edwards, Emsley, Evans, Fairhead, Fuxreiter, Gao, Gekakis, Griffin, Gustafson, Hirota, Hitomi, Huang, Khan, Kim, Kiyohara, Koike, Lee, Levy, Li, Lindorff-Larsen, Liu, Liu, Ludtke, López-Llano, McClendon, McGibbon, Michael, Michael, Miyazaki, Moffett, Nangle, Ode, Park, Park, Parrinello, Partch, Partch, Patke, Pettersen, Preitner, Rapp, Rosensweig, Sancar, Sato, Scheres, Schmalen, Suloway, Takahashi, Ukai-Tadenuma, van der Horst, van Zundert, Vitaterna, Voss, Wagner, Winn, Xing, Xu, Yagita, Zhang, Zhu   +70 more
core   +3 more sources

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Clp P represents a unique family of serine proteases.

Journal of Biological Chemistry, 1990
The amino acid sequence of Clp P, the proteolytic subunit of the ATP-dependent Clp protease of Escherichia coli, closely resembles a protein encoded by chloroplast DNA, which is well conserved between chloroplasts of different plant species. The homology extends over almost the full length of the sequences of both proteins and consists of approximately
M R, Maurizi, W P, Clark, S H, Kim, S, Gottesman   +3 more
openaire   +2 more sources

Structure and Function of a Novel Type of ATP-dependent Clp Protease [PDF]

Journal of Biological Chemistry, 2009
The Clp protease is conserved among eubacteria and most eukaryotes, and uses ATP to drive protein substrate unfolding and translocation into a chamber of sequestered proteolytic active sites. The main constitutive Clp protease in photosynthetic organisms has evolved into a functionally essential and structurally intricate enzyme. The model Clp protease
Andersson, F., Tryggvesson, A., Sharon, M., Diemand, A., Classen, M., Best, C., Schmidt, R., Schelin, J., Stanne, T., Bukau, B., Robinson, C., Witt, S., Mogk, A., Clarke, A.   +13 more
openaire   +5 more sources

Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis

Nature Communications
The caseinolytic protease (Clp) system has recently emerged as a promising anti-tuberculosis target. The anti-cancer drug bortezomib exhibits potent anti-mycobacterial activity and binds to Mycobacterium tuberculosis (Mtb) Clp protease complexes.
Biao Zhou, Yamin Gao, Heyu Zhao, Banghui Liu, Han Zhang, Cuiting Fang, Hang Yuan, Jingjing Wang, Zimu Li, Yi Zhao, Xiaodong Huang, Xiyue Wang, A. Sofia. F. Oliveira, James Spencer, Adrian J. Mulholland, Steven G. Burston, Jinxing Hu, Ning Su, Xinwen Chen, Jun He, Tianyu Zhang, Xiaoli Xiong   +21 more
doaj   +1 more source

Improved biocontrol performance of acid-tolerant Pseudomonas koreensis CLP-23 against Ralstonia solanacearum causing tobacco wilt

Biological Control
Pseudomonas koreensis, a subgroup of the P. fluorescens complex, is a potential plant growth-promoting rhizobacterium. The aim of this study was to evaluate the biocontrol effects of Pseudomonas koreensis CLP-23 against R.
Guozheng Zhang, Wei Lin, Jianyang Liu, Yong Lin, Chao Ye, Tianbo Liu, Jing Wang   +6 more
doaj   +1 more source