Results 51 to 60 of about 171,782 (185)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction [PDF]

Advanced science
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Meng N, Zhou J, Guo X, Hong T, Li X, Wei X, Zhang C, Zhang X, Liu S, Zhang Y, Yao L, Huang L, Gu W.   +12 more
europepmc   +2 more sources

Identification and characterization of novel Clp protease interaction partners in Mycolicibacterium smegmatis

, 2022
Schmitz, Karl R.Tuberculosis remains a leading cause of worldwide infectious mortality and one of the top ten leading causes of death overall. While advances in public health have contributed to a reduction in tuberculosis cases, the prevalence of ...
Ogbonna, Emmanuel Chidirim
core   +1 more source

Simultaneous Ablation of the Catalytic AMPK α-Subunit SNF1 and Mitochondrial Matrix Protease CLPP Results in Pronounced Lifespan Extension

Frontiers in Cell and Developmental Biology, 2021
Organismic aging is known to be controlled by genetic and environmental traits. Pathways involved in the control of cellular metabolism play a crucial role.
Daniela Heinz, Evgeniia Krotova, Andrea Hamann, Heinz D. Osiewacz   +3 more
doaj   +1 more source

Cervimycin-Resistant Staphylococcus aureus Strains Display Vancomycin-Intermediate Resistant Phenotypes

Microbiology Spectrum, 2022
Resistance to antibiotics is an increasing problem and necessitates novel antibacterial therapies. The polyketide antibiotics cervimycin A to D are natural products of Streptomyces tendae HKI 0179 with promising activity against multidrug-resistant ...
Alina Dietrich, Ursula Steffens, Mike Gajdiss, Anna-Lena Boschert, Jana Katharina Dröge, Christiane Szekat, Peter Sass, Imran T. Malik, Jan Bornikoel, Laura Reinke, Boris Maček, Mirita Franz-Wachtel, Kay Nieselt, Theresa Harbig, Kirstin Scherlach, Heike Brötz-Oesterhelt, Christian Hertweck, Hans-Georg Sahl, Gabriele Bierbaum   +18 more
doaj   +1 more source

Structural insights into the Clp protein degradation machinery

mBio
The Clp protease system is important for maintaining proteostasis in bacteria. It consists of ClpP serine proteases and an AAA+ Clp-ATPase such as ClpC1.
Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long   +5 more
doaj   +1 more source

The GluTR-binding protein is the heme-binding factor for feedback control of glutamyl-tRNA reductase

eLife, 2019
Synthesis of 5-aminolevulinic acid (ALA) is the rate-limiting step in tetrapyrrole biosynthesis in land plants. In photosynthetic eukaryotes and many bacteria, glutamyl-tRNA reductase (GluTR) is the most tightly controlled enzyme upstream of ALA.
Andreas S Richter, Claudia Banse, Bernhard Grimm   +2 more
doaj   +1 more source

Co-regulation of Thermosensor Pathogenic Factors by C-di-GMP-Related Two-Component Systems and a cAMP Receptor-like Protein (Clp) in Stenotrophomonas maltophilia

Foods
Stenotrophomonas maltophilia is a major threat to the food industry and human health owing to its strong protease production and biofilm formation abilities. However, information regarding regulatory factors or potential mechanisms is limited. Herein, we
Jieqiong Ding, Minghong Liao, Qingling Wang   +2 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Temporal Proteomics of Inducible RNAi Lines of Clp Protease Subunits Identifies Putative Protease Substrates [PDF]

Plant Physiology, 2017
The Clp protease in the chloroplasts of plant cells is a large complex composed of at least 13 nucleus-encoded subunits and one plastid-encoded subunit, which are arranged in several ring-like structures. The proteolytic P-ring and the structurally similar R-ring form the core complex that contains the proteolytic chamber.
Juan C. Moreno, Silvia Martínez-Jaime, Joram Schwartzmann, Daniel Karcher, Michael Tillich, Alexander Graf, Ralph Bock   +6 more
openaire   +3 more sources

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain [PDF]

, 2013
Mitochondrial maintenance crucially depends on the quality control of proteins by various chaperones, proteases and repair enzymes. While most of the involved components have been studied in some detail, little is known on the biological role of the ...
Fischer, Fabian, Hamann, Andrea, Weil, Andrea, Osiewacz, Heinz D.   +3 more
core   +1 more source