Results 31 to 40 of about 171,782 (185)

NETosis in the Kidney, Liver, and Lung of Mice With Cecal Ligation and Puncture-Induced Sepsis and the Ameliorating Effects of Adipose-Derived Stem Cell Exosomes. [PDF]

Kaohsiung J Med Sci
ABSTRACT Sepsis‐induced organ failure involves dysregulated neutrophil responses, including neutrophil extracellular trap (NET) formation, via NETosis. Exosomes generated from adipose‐derived stem cells (ADSCs) have shown potential in sepsis treatment. This study characterized organ‐specific NETosis in the kidney, liver, and lungs using a murine cecal ...
Wu SC, Lu TH, Wu YC, Lin CW, Tsai CW, Hsieh CH.   +5 more
europepmc   +2 more sources

Protective Roles of Cytosolic and Plastidal Proteasomes on Abiotic Stress and Pathogen Invasion

Plants, 2020
Protein malfunction is typically caused by abiotic stressors. To ensure cell survival during conditions of stress, it is important for plant cells to maintain proteins in their respective functional conformation.
Md. Sarafat Ali, Kwang-Hyun Baek
doaj   +1 more source

Acinetobacter baumannii Strains Deficient in the Clp Chaperone-Protease Genes Have Reduced Virulence in a Murine Model of Pneumonia

Pathogens, 2021
Acinetobacter baumannii has emerged as a significant opportunistic Gram-negative pathogen and causative agent of nosocomial pneumonia especially in immunocompromised individuals in intensive care units.
J Christian Belisario, Hiu Ham Lee, Harshani Luknauth, Nathan W. Rigel, Luis R. Martinez   +4 more
doaj   +1 more source

ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage [PDF]

, 2010
Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence.
Smith, H.E., Butler, R.E., Thole, J.E.R., Harders-Westerveen, S.F., Kierzek, A., Neyrolles, O., Estorninho, M., Stewart, G.R., Estorninho, M, Jelle Thole, Harders-Westerveen, J, Butler, RE, Graham R. Stewart, Jose Harders-Westerveen, Neyrolles, O, Hilde Smith, Thole, J, Rachel E. Butler, Smith, H, Kierzek, A, Olivier Neyrolles, Stewart, GR, Andrzej Kierzek, Megan Estorninho   +23 more
core   +1 more source

The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development

mBio, 2020
Chlamydia trachomatis is an obligate intracellular bacterium that undergoes a complex developmental cycle in which the bacterium differentiates between two functionally and morphologically distinct forms, the elementary body (EB) and reticulate body (RB),
Nicholas A. Wood, Amanda M. Blocker, Mohamed A. Seleem, Martin Conda-Sheridan, Derek J. Fisher, Scot P. Ouellette   +5 more
doaj   +1 more source

Targeting the Clp Protease for Mycobacterial Drug Development

Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis (Mtb), remains one of the deadliest and most widespread infectious diseases worldwide. Although antibiotic therapy for TB has existed for several decades, drug resistance has made the disease increasingly difficult to treat and cure. Today, there are more than 400,000 estimated cases
Zinga, Samuel
core   +3 more sources

Role of ClpP in the Biogenesis and Degradation of RuBisCO and ATP Synthase in Chlamydomonas reinhardtii

Plants, 2019
Ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO) associates a chloroplast- and a nucleus-encoded subunit (LSU and SSU). It constitutes the major entry point of inorganic carbon into the biosphere as it catalyzes photosynthetic CO2 fixation.
Wojciech Majeran, Katia Wostrikoff, Francis-André Wollman, Olivier Vallon   +3 more
doaj   +1 more source

SUBSTRATES, STRUCTURES, AND FUNCTIONS OF THE CHLOROPLAST CLP PROTEASE SYSTEM IN ARABIDOPSIS THALIANA [PDF]

, 2019
The caseinolytic proteolytic machinery (CLP) is an essential and abundant protease of the chloroplast protease network. It is composed of multiple components (a proteolytic core CLPP/R/T, chaperones CLPC1/C2/D, and adaptors CLPS1/F).
Liao, Juiyun
core   +1 more source

CLP

, 2022
Alignments of nuclear-encoded genes that conform the plastid CLP ...
Luis Federico Ceriotti (11956136)
core   +1 more source

Loss of the ClpXP Protease Leads to Decreased Resistance to Cell-Envelope Targeting Antimicrobials in Bacillus anthracis Sterne

Frontiers in Microbiology, 2021
The ClpX ATPase is critical for resistance to cell envelope targeting antibiotics in Bacillus anthracis, however, it is unclear whether this is due to its function as an independent chaperone or as part of the ClpXP protease.
Lang Zou, Christopher R. Evans, Vuong D. Do, Quinn P. Losefsky, Diem Q. Ngo, Shauna M. McGillivray   +5 more
doaj   +1 more source