Results 81 to 90 of about 171,782 (185)

Clp protease and OR directly control the proteostasis of phytoene synthase, the crucial enzyme for carotenoid biosynthesis in Arabidopsis

, 2021
Ajuts: This work was supported by Agriculture and Food Research Initiative competitive award no. 2016-67013-24612 from the USDA National Institute of Food and Agriculture and by the HarvestPlus research consortium (2014H6320.FRE)Phytoene synthase (PSY ...
Li, Li, Shen, Guoxin, Zhou, Xiangjun, Schlossarek, Dennis, Zhang, Hong, Welsch, Ralf, Thannhauser, Theodore W., Álvarez, Daniel, Sun, Tianhu, Rodríguez Concepción, Manuel, Yuan, Hui, Yang, Yong   +11 more
core  

Mutations in ClpC1 or ClpX subunit of caseinolytic protease confer resistance to ilamycins in mycobacteria

Communications Biology
The mycobacterial caseinolytic protease (Clp) system has been recognized as a promising therapeutic target. In this study, we identify two novel ilamycin analogs, ilamycin E (ILE) and ilamycin F (ILF), both targeting the ClpC1 component of the ClpC1P1P2 ...
Yamin Gao, Cuiting Fang, Biao Zhou, H. M. Adnan Hameed, Changli Sun, Xirong Tian, Jing He, Xingli Han, Han Zhang, Jun Li, Jianhua Ju, Xinwen Chen, Nanshan Zhong, Junying Ma, Xiaoli Xiong, Tianyu Zhang   +15 more
doaj   +1 more source

Sepsis: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 11, November 2026.
Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan, Yu Deng, Lin‐Rui Ma, Yu‐Tong Li, Yu Qian, Yi‐Hua Ma, Hai‐Wei Rao, Yi‐Zhun Zhu, Pei‐Yu Yan   +8 more
wiley   +1 more source

Interference with Clp protease impairs carotenoid accumulation during tomato fruit ripening

, 2021
Profound metabolic and structural changes are required for fleshy green fruits to ripen and become colorful and tasty. In tomato (Solanum lycopersicum), fruit ripening involves the differentiation of chromoplasts, specialized plastids that accumulate ...
Llorente, Briardo, Loza-Alvarez, Pablo, Llamas, Ernesto, D'Andrea, Lucio, Simon-Moya, Miquel, Marro, Mónica, Rodríguez Concepción, Manuel, Li Li   +7 more
core  

Manipulation of Plastidial Protein Quality Control Components as a New Strategy to Improve Carotenoid Contents in Tomato Fruit

Frontiers in Plant Science, 2019
Carotenoids such as β-carotene (pro-vitamin A) and lycopene accumulate at high levels during tomato (Solanum lycopersicum L.) fruit ripening, contributing to the characteristic color and nutritional quality of ripe tomatoes.
Lucio D’Andrea, Manuel Rodriguez-Concepcion, Manuel Rodriguez-Concepcion   +2 more
doaj   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

ClpS1 Is a Conserved Substrate Selector for the Chloroplast Clp Protease System in Arabidopsis [PDF]

The Plant Cell, 2013
Whereas the plastid caseinolytic peptidase (Clp) P protease system is essential for plant development, substrates and substrate selection mechanisms are unknown. Bacterial ClpS is involved in N-degron substrate selection and delivery to the ClpAP protease.
Kenji, Nishimura, Yukari, Asakura, Giulia, Friso, Jitae, Kim, Soo-Hyun, Oh, Heidi, Rutschow, Lalit, Ponnala, Klaas J, van Wijk   +7 more
openaire   +2 more sources

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Proteomic Analysis of a Leaf Spot Pathogen, Xanthomonas euvesicatoria pv. euvesicatoria 173 upon Sublethal Dose of Cinnamon Essential Oil [PDF]

The Plant Pathology Journal
Cinnamon essential oil (CEO) exhibits antimicrobial activity in a dose-dependent manner, offering potential for controlling plant bacterial diseases. This study investigated the effects of CEO on Xanthomonas euvesicatoria pv.
Hyo-Song Nam, Yu-Na Kim, Jeong-Yong Cho, Young Cheol Kim   +3 more
doaj   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source