Results 181 to 190 of about 18,135 (204)
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ClpP: A structurally dynamic protease regulated by AAA+ proteins
Journal of Structural Biology, 2012Proteolysis is an important process for many aspects of bacterial physiology. Clp proteases carry out a large proportion of protein degradation in bacteria. These enzymes assemble in complexes that combine the protease ClpP and the unfoldase, ClpA or ClpX.
John A, Alexopoulos +2 more
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Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice
Journal of Hepatology, 2022Mitochondrial dysfunction is considered a pathogenic linker in the development of non-alcoholic steatohepatitis (NASH). Inappropriate mitochondrial protein-quality control, possibly induced by insufficiency of the mitochondrial matrix caseinolytic protease P (ClpP), can potentially cause mitochondrial dysfunction.
Sung-E Choi +13 more
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An amino acid domino effect orchestrates ClpP's conformational states
Current Opinion in Chemical Biology, 2017Maintaining the cellular protein homeostasis means managing life on the brink of death. This balance is largely based on precise fine-tuning of enzyme activities. For instance, the ClpP protease possesses several conformational switches which are fundamental to regulating its activity.
Matthias, Stahl, Stephan A, Sieber
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The regulation of Porphyromonas gingivalis biofilm formation by ClpP
Biochemical and Biophysical Research Communications, 2019Porphyromonas gingivalis is one of the most commonly detected pathogens in periodontal disease and root canal infections. Its viability and pathogenicity are greatly increased in plaque biofilms. Some caseinolytic proteases (Clp) reportedly regulate biofilm formation by various pathogenic bacteria, including P. gingivalis.
Lu, He +3 more
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The development of small-molecule modulators for ClpP protease activity
Molecular BioSystems, 2017Deregulating ClpP activity either through inhibition or overactivation could lead to antibacterial activity.
Fei, Ye, Jiahui, Li, Cai-Guang, Yang
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Patenting perspective of modulators of ClpP endopeptidase: 2019-present
Expert Opinion on Therapeutic PatentsClpP is a highly conserved serine protease that plays a crucial role in maintaining protein homeostasis in both bacterial cells and human mitochondria. Several studies have demonstrated the potential of ClpP as a drug target, with ClpP modulators, including both inhibitors and activators, showing promise in treating a range of conditions such as drug ...
Zhenyu, Wang +3 more
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The Role of ClpP in Protein Expression of Streptococcus pneumoniae
Current Microbiology, 2011Previous reports suggest that ClpP proteolytic activity is important not only for cell physiology but also for regulation of virulence properties of Streptococcus pneumoniae (S. pneumoniae). In order to get a more comprehensive picture of the role of ClpP protease on protein expression in S. pneumoniae D39 and how it relates to physiology and virulence,
Qun, Zhang +6 more
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Selektive Aktivierung der humanen caseinolytischen Protease P (ClpP)
Angewandte Chemie, 2018AbstractDie caseinolytische Protease P (ClpP) ist die proteolytische Komponente des Protein‐Abbau‐Komplexes ClpXP. Ihre genaue Funktion und Regulation sind größtenteils unerforscht. Hier stellen wir eine niedermolekulare Verbindung (D9) vor, die durch Nachahmung des natürlichen Chaperons ClpX als potenter und Spezies‐selektiver Aktivator der humanen ...
Matthias Stahl +9 more
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Assessing CLPPs using MicroResp™
Journal of Soils and Sediments, 2007Stephen J. Chapman +2 more
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Der Inhibitionsmechanismus der caseinolytischen Protease (ClpP)
Angewandte Chemie, 2013Gersch, M. +9 more
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