Results 51 to 60 of about 54,597 (215)

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Detection of Extended Spectrum Bet-Lactamases in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae in Asia-Pacific Region [PDF]

Iranian Journal of Public Health, 2007
Background: The CLSI screening and confirmatory methods are recommended by CLSI for detection of extended- spectrum β- lactamases in Escherichia coli (ECOL), Klebsiella pneumoniae (KPNE) and Klebsiella oxytoca.
M Chitsaz, JM BELL, JD Turnidge, MD Barton, M Bazargan   +4 more
doaj   +1 more source

Proposed Meropenem Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Bacteria Isolated From Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Meropenem is a carbapenem antibiotic used infrequently in veterinary medicine. However, antimicrobial susceptibility testing standards are needed to monitor for resistance caused by carbapenem resistant Enterobacterales (CRE). The Clinical and Laboratory Standards Institute (CLSI) does not have veterinary‐specific carbapenem breakpoints for ...
Mark G. Papich, Marilyn N. Martinez
wiley   +1 more source

Uptake of Revised CLSI Breakpoints and Potential Impact among Hospitals Reporting to The NHSN AR Option, 2022

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Antimicrobial susceptibility testing (AST) is critical for detecting antimicrobial resistance (AR) and guiding antimicrobial treatment. The Clinical and Laboratory Standards Institute (CLSI) regularly publishes and revises breakpoints to ...
Allan Nkwata, Rupert England, Laura Blum, Hsiu Wu   +3 more
doaj   +1 more source

Does the adoption of EUCAST susceptibility breakpoints affect the selection of antimicrobials to treat acute community-acquired respiratory tract infections?

BMC Infectious Diseases, 2012
Background In several European Countries, by the end of 2012, CLSI guidelines will be replaced by EUCAST. We compared antimicrobial susceptibility results of a large number of respiratory pathogens using both EUCAST and previously adopted CLSI criteria ...
Marchese Anna, Esposito Susanna, Barbieri Ramona, Bassetti Matteo, Debbia Eugenio   +4 more
doaj   +1 more source

Photodynamic inactivation increases cell death rate on persistent Staphylococcus aureus

Photochemistry and Photobiology, EarlyView.
Persistent bacteria have the ability to survive extended periods of antibiotic stress by entering a metabolically dormant state. This study investigated persistence formation in two S. aureus strains and evaluated the effects of PDI using curcumin. Post‐PDI time‐kill assays conducted after metabolic recovery showed a higher rate of bacterial death ...
Maria Vitória Silva Pereira, Bruna Carolina Corrêa, Vanderlei Salvador Bagnato, Kate Cristina Blanco   +3 more
wiley   +1 more source

The Role of Nontuberculous Mycobacteria in Patients With Cystic Fibrosis Advanced Lung Disease

Transplant Infectious Disease, EarlyView.
Among 270 cystic fibrosis patients, 20.7% were NTM‐positive and had a lower pre‐transplant risk of death or lung transplantation but higher post‐transplant mortality, with no difference in CLAD incidence. These results suggest NTM infection should not be an absolute contraindication to lung transplantation, though careful individual risk assessment is ...
Shirin Barcikowski, Ribal Bou Mjahed, Oriol Manuel, Macé M. Schuurmans, Adrian Alonso, Zisis Balmpouzis, Jesica Mazza‐Stalder, Angela Koutsokera, Nicolas J. Mueller   +8 more
wiley   +1 more source

In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris

Journal of Infection in Developing Countries, 2016
Introduction: Propionibacterium acnes has been implicated in the development of acne vulgaris. Rampant use of topical and systemic antibiotics for acne vulgaris has led to resistance due to selective pressure.
Indu Biswal, Rajni Gaind, Neeraj Kumar, Srujana Mohanty, Vikas Manchanda, Niti Khunger, Ramesh V, Monorama Deb   +7 more
doaj   +1 more source

Fosmidomycin for the Treatment of Canine Otitis Externa: A Randomised, Double‐Blinded, Controlled ‘Split Body’ Clinical Trial

Veterinary Dermatology, EarlyView.
ABSTRACT Background Targeted antimicrobial therapy for canine otitis externa (OE) represents an opportunity for antimicrobial stewardship. Fosmidomycin selectively inhibits the non‐mevalonate pathway for isoprenoid biosynthesis utilised by canine‐adapted, and not human‐adapted, staphylococci.
Lindsey E. Citron, Darko Stefanovski, Youwen You, Rachel Proctor, Donna Watson, Julie Randall, Christine L. Cain   +6 more
wiley   +1 more source

Role of CLSI in Assuring Quality Testing in Clinical Laboratories [PDF]

The Journal of Applied Laboratory Medicine, 2016
The Clinical and Laboratory Standards Institute (CLSI) was founded nearly 50 years ago by clinicians and laboratory scientists as a not-for-profit standards development organization with the intention to work collaboratively on ways to ensure the quality of laboratory testing, improve patient care, and develop a formal consensus process for ...
openaire   +2 more sources