Results 81 to 90 of about 321,235 (338)

La «Machine Jacobine»? un Fantasme Historiographique Revisité à l'aune d'un Exemple local: la Société Populaire de Honfleur (1791-1795)

open access: yesHistoria Social y de la Educación, 2015
Outre les anciennes diatribes de Cochin contre la sociabilité jacobine, remises au goût du jour dans les années 1970, l’histoire des sociétés populaires, clubs politiques apparus pendant la Révolution française, a également dû compter avec nombre de ...
Michel Biard
doaj   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

Animation socioculturelle et revalorisation des jeux traditionnels en Côte d’Ivoire

open access: yesRevue Internationale Animation, Territoires et Pratiques Socioculturelles
Cet article vise à examiner l’évolution paradoxale de l’animation socioculturelle en Côte d’Ivoire à partir du processus de mise en place et du fonctionnement des clubs de jeux traditionnels.
Koffi Roland Bini
doaj   +1 more source

Self-determination “Without a Mask” in Performing Arts and in Their Perception in the 1960s-1980s [PDF]

open access: yesХудожественная культура
This work contains an attempt to understand the sources, evolution and results of the phenomenon of personal sincerity in the Soviet performing arts of the 1960s-1980s.
Tulchinskii Grigorii L.
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Which wider social roles? An analysis of social roles ascribed to voluntary sports clubs

open access: yes, 2016
It has long been established that voluntary sports clubs (VSCs) are ascribed a prominent social role by governments. Several scholars highlight the ascribed social values in sport policy to voluntary sports clubs and their possible implications for these
Maikel Waardenburg
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

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