Results 91 to 100 of about 4,170,754 (298)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Economic Integration in the System of Spatial Development of the Region
Вестник Российского экономического университета имени Г. В. Плеханова, 2020 The article studies specific features of economic integration processes in the context of regional market space clustering. Methodological principles of today’s cluster systems are shown and their signs are identified with signs of heterogeneous network ...
T. N. Topoleva
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
MicrobiomeBackground Reciprocal exchanges of metabolites between phytoplankton and bacteria influence the fitness of these microorganisms which ultimately shapes the productivity of marine ecosystems.
Abeeha Khalil +7 more
doaj +1 more source
Upgrading Mechanisms of Managing Social and Economic Development of Tourism on Regional Level
Вестник Российского экономического университета имени Г. В. Плеханова, 2020 Mechanisms of developing tourism on the regional level are numerous and they can be systematized by different characteristics. However, it is better to give a general view of the system of such mechanisms through classical management functions that ...
S. B. Boldyreva
doaj +1 more source
, 1999 Cluster algorithms have been recently used to eliminate sign problems that plague Monte-Carlo methods in a variety of systems. In particular such algorithms can also be used to solve sign problems associated with the permutation of fermion world lines ...
Bietenholz +2 more
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Cluster cosmology without cluster finding
Monthly Notices of the Royal Astronomical SocietyABSTRACT We propose that observations of supermassive galaxies contain cosmological statistical constraining power similar to conventional cluster cosmology, and we provide promising indications that the associated systematic errors are comparably easier to control. We consider a fiducial spectroscopic and stellar mass complete sample of
Enia Xhakaj +7 more
openaire +2 more sources