Results 41 to 50 of about 124,654 (199)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Electroweak symmetry breaking and collider signatures in the next-to-minimal composite Higgs model

Journal of High Energy Physics, 2017
We conduct a detailed numerical analysis of the composite pseudo-Nambu-Goldstone Higgs model based on the next-to-minimal coset SO(6)/SO(5) ≅ SU(4)/Sp(4), featuring an additional SM singlet scalar in the spectrum, which we allow to mix with the Higgs ...
Christoph Niehoff, Peter Stangl, David M. Straub   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

Cell Death and Disease
Constitutive mitochondrial dynamics ensure quality control and metabolic fitness of cells, and their dysregulation has been implicated in various human diseases.
Lohans Pedrera, Laura Prieto Clemente, Alina Dahlhaus, Sara Lotfipour Nasudivar, Sofya Tishina, Daniel Olmo González, Jenny Stroh, Fatma Isil Yapici, Randhwaj Pratap Singh, Nils Grotehans, Thomas Langer, Ana J. García-Sáez, Silvia von Karstedt   +12 more
doaj   +1 more source

Infraestructura de HPC del Colaboratorio Nacional de Computación Avanzada, Kabré

Tecnología en Marcha, 2020
La supercomputadora Kabré es un clúster de computación de alto rendimiento (HPC) que proporciona las herramientas necesarias para ejecutar proyectos específicos.
Isaac Eduardo Gómez-Sánchez, Jean Carlo Umaña-Jiménez, Melissa Arce-Montero   +2 more
doaj   +1 more source

Cluster-tilted algebras without clusters

Journal of Algebra, 2010
Cluster-tilted algebras are trivial extensions of tilted algebras. This correspondence induces a surjective map from tilted algebras to cluster-tilted algebras. If B is a cluster-tilted algebra, we use the fibre of B under this map to study the module category of B.
Assem, Ibrahim, Brüstle, Thomas, Schiffler, Ralf   +2 more
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Monitoring of the Inner Ear Function During and After Cochlear Implant Insertion Using Electrocochleography

Trends in Hearing, 2019
To preserve residual hearing during cochlear implant (CI) surgery, it is desirable to use intraoperative monitoring of inner ear function (cochlear monitoring), especially during electrode insertion.
Sabine Haumann, Marina Imsiecke, Günther Bauernfeind, Andreas Büchner, Victor Helmstaedter, Thomas Lenarz, Rolf B. Salcher   +6 more
doaj   +1 more source

Anatomy of $$\varepsilon '/\varepsilon $$ ε′/ε beyond the standard model

European Physical Journal C: Particles and Fields, 2019
We present for the first time a model-independent anatomy of the ratio $$\varepsilon '/\varepsilon $$ ε′/ε in the context of the $$\Delta S = 1$$ ΔS=1 effective theory with operators invariant under QCD and QED and in the context of the standard model ...
Jason Aebischer, Christoph Bobeth, Andrzej J. Buras, David M. Straub   +3 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source