Results 61 to 70 of about 2,076,484 (318)
Molecular characterization of breast cancer cell lines through multiple omic approaches
Breast Cancer Research, 2017 Background Breast cancer cell lines are frequently used as model systems to study the cellular properties and biology of breast cancer. Our objective was to characterize a large, commonly employed panel of breast cancer cell lines obtained from the ...
Shari E. Smith +8 more
doaj +1 more source
Correlation clustering with a fixed number of clusters [PDF]
Proceedings of the seventeenth annual ACM-SIAM symposium on Discrete algorithm - SODA '06, 2006 We continue the investigation of problems concerning correlation clustering or clustering with qualitative information, which is a clustering formulation that has been studied recently. The basic setup here is that we are given as input a complete graph on n nodes (which correspond to nodes to be clustered) whose edges are labeled + (for similar pairs ...
Ioannis Giotis 0001 +1 more
openaire +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Infraestructura de HPC del Colaboratorio Nacional de Computación Avanzada, Kabré
Tecnología en Marcha, 2020 La supercomputadora Kabré es un clúster de computación de alto rendimiento (HPC) que proporciona las herramientas necesarias para ejecutar proyectos específicos.
Isaac Eduardo Gómez-Sánchez +2 more
doaj +1 more source
On the Elusiveness of Clusters
IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2012 Rooted phylogenetic networks are often used to represent conflicting phylogenetic signals. Given a set of clusters, a network is said to represent these clusters in the "softwired" sense if, for each cluster in the input set, at least one tree embedded in the network contains that cluster.
S.M. Kelk (Steven) +2 more
openaire +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Electroweak symmetry breaking and collider signatures in the next-to-minimal composite Higgs model
Journal of High Energy Physics, 2017 We conduct a detailed numerical analysis of the composite pseudo-Nambu-Goldstone Higgs model based on the next-to-minimal coset SO(6)/SO(5) ≅ SU(4)/Sp(4), featuring an additional SM singlet scalar in the spectrum, which we allow to mix with the Higgs ...
Christoph Niehoff +2 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source