Results 51 to 60 of about 124,654 (199)
The Role of Education in Economic Growth: An Exploratory Literature Review
Экономика: стратегия и практика, 2023 Human capital occupies a leading position in economic development and determines the importance of education as a system responsible for its production. Attention has increasingly been paid in recent years to the role of education in the economic growth ...
S. K. Kondybayeva +3 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Journal of Infection in Developing Countries, 2020 Introduction: Since the first reports of coronavirus disease 2019 (COVID-19) in December 2019, the disease has spread worldwide. Different social isolation strategies have been adopted to reduce community transmission, but few studies have evaluated the
Carlos Alexandre Antunes de Brito +5 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Computational Statistics & Data Analysis, 2013 23 pages, 6 ...
Yan, Donghui +2 more
openaire +3 more sources
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Engineering Applications of Computational Fluid Mechanics, 2019 The European Union is setting increasingly challenging targets for the waste recycling rates of its member states. This makes improvements in recycling processes, such as dense medium metal separation, a necessity.
Arne Eggers +5 more
doaj +1 more source
Infrastructure and Energy Conservation in Big Data Computing: A Survey
Journal of Telecommunications and Information Technology, 2019 Progress in life, physical sciences and technology depends on efficient data-mining and modern computing technologies. The rapid growth of data-intensive domains requires a continuous development of new solutions for network infrastructure, servers and ...
Ewa Niewiadomska-Szynkiewicz +1 more
doaj +1 more source