Results 191 to 200 of about 1,705,145 (242)

Clustered DNA damage on subcellular level: effect of scavengers

Radiation and Environmental Biophysics, 2014
Clustered DNA damages are induced by ionizing radiation, particularly of high linear energy transfer (LET). Compared to isolated DNA damage sites, their biological effects can be more severe. We investigated a clustered DNA damage induced by high LET radiation (C 290 MeV u(-1) and Fe 500 MeV u(-1)) in pBR322 plasmid DNA.
Kateřina, Pachnerová Brabcová, Lembit, Sihver, Nakahiro, Yasuda, Youichirou, Matuo, Václav, Stěpán, Marie, Davídková   +5 more
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Are Endogenous Clustered Dna Damages Induced in Human Cells?

Free Radical Biology and Medicine, 2004
Although clustered DNA damages are induced in cells by ionizing radiation and can be induced artifactually during DNA isolation, it was not known if they are formed in unirradiated cells by normal oxidative metabolism. Using high-sensitivity methods of quantitative gel electrophoresis, electronic imaging, and number average length analysis, we found ...
Betsy M Sutherland, Jacques Laval, Paula V Bennett   +2 more
exaly   +3 more sources

Molecular Dynamics Simulation of Clustered DNA Damage Sites Containing 8-Oxoguanine and Abasic Site

Journal of Computational Chemistry, 2005
Clustered DNA damage sites induced by ionizing radiation have been suggested to have serious consequences to organisms, such as cancer, due to their reduced probability to be repaired by the enzymatic repair machinery of the cell.
Miroslav Pinak, Hideaki Maekawa, Peter O'Neill   +2 more
exaly   +2 more sources

Progression of Visual Field Damage within Clusters Depends on Preexisting Damage

Klinische Monatsblätter für Augenheilkunde, 2022
Abstract Purpose To investigate, in a routine clinical setting, how global progression or progression within visual field clusters depends on preexisting damage. Methods Glaucoma patients with a visual field damage of at least 3 dB at baseline and a series of at least 5 good quality examinations were scrutinized retrospectively. The
Lukas Burkart, Florentina Freiberg, Selim Orguel   +2 more
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Analysis of Cluster Damages in Network Systems

Computational Mathematics and Mathematical Physics, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Malashenko, Yu. E., Nazarova, I. A., Novikova, N. M.   +2 more
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Investigation on the Correlation Between Energy Deposition and Clustered DNA Damage Induced by Low-Energy Electrons

Radiation and Environmental Biophysics, 2018
International audienceThis study presents the correlation between energy deposition and clustered DNA damage, based on a Monte Carlo simulationof the spectrum of direct DNA damage induced by low-energy electrons including the dissociative electron ...
Christophe Champion, Zhang, Liming, Liu, Wei, Tan, Zhenyu, Champion, Christophe, Zhenyu Tan, Liming Zhang, Wei Liu   +7 more
exaly   +2 more sources

Structure and Energetics of Clustered Damage Sites

Radiation Research, 2005
Quantum calculations on duplex DNA trimers were used to model the changes in structure, hydrogen bonding, stacking properties, and electrostatic potential induced by oxidized purine bases and abasic (AP) sites. Results for oxidized purine bases were consistent with experimental data that show small structural and energetic perturbations induced by ...
J H, Miller, A, Aceves-Gaona, M B, Ernst, M, Haranczyk, M, Gutowski, E R, Vorpagel, M, Dupuis   +6 more
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Radiation Induced Clustered Damage in DNA

Free Radical Research Communications, 1989
(1989). Radiation Induced Clustered Damage in DNA. Free Radical Research Communications: Vol. 6, No. 2-3, pp. 177-178.
U, Hagen, H, Bertram, E M, Geigl, E, Kohfeldt, S, Wendel   +4 more
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Repair of clustered damage and DNA polymerase iota

Biochemistry (Moscow), 2015
Multiple DNA lesions occurring within one or two turns of the DNA helix known as clustered damage are a source of double-stranded DNA breaks, which represent a serious threat to the cells. Repair of clustered lesions is accomplished in several steps.
E A, Belousova, O I, Lavrik
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Pipeline Damage Assessment Using Cluster Analysis

TCLEE 2009, 2009
Clustering techniques are used commonly in a variety of engineering and scientific fields although it is rarely used in lifeline earthquake engineering. Cluster analysis deals primarily with the discovery of structures or groupings within data. This paper presents the application of cluster analysis in pipeline damage assessment and identification of ...
Toprak, Selçuk, Nacaroğlu, Engin, Cetin, O.A., Koç, Abdullah Cem   +3 more
openaire   +2 more sources