Results 61 to 70 of about 161,459 (317)

Calculation of complex DNA damage induced by ions

, 2011
This paper is devoted to the analysis of the complex damage of DNA irradiated by ions. The analysis and assessment of complex damage is important because cells in which it occurs are less likely to survive because the DNA repair mechanisms may not be ...
Gallagher, David C., Solov'yov, Andrey V., Surdutovich, Eugene   +2 more
core   +1 more source

Risks from low dose/dose rate radiation: what an understanding of DNA damage response mechanisms can tell us [PDF]

, 2009
The DNA damage response (DDR) mechanisms represent a vital line of defense against exogenous and endogenous DNA damage to enhance two distinct outcomes, survival and the maintenance of genomic stability. The latter is critical for cancer avoidance.
Jeggo, Peggy A.
core   +2 more sources

Visualisation of γH2AX foci caused by heavy ion particle traversal; distinction between core track versus non-track damage.

PLoS ONE, 2013
Heavy particle irradiation produces complex DNA double strand breaks (DSBs) which can arise from primary ionisation events within the particle trajectory.
Nakako Izumi Nakajima, Holly Brunton, Ritsuko Watanabe, Amruta Shrikhande, Ryoichi Hirayama, Naruhiro Matsufuji, Akira Fujimori, Takeshi Murakami, Ryuichi Okayasu, Penny Jeggo, Atsushi Shibata   +10 more
doaj   +1 more source

Multiscale approach to radiation damage induced by ion beams: complex DNA damage and effects of thermal spikes

, 2010
We present the latest advances of the multiscale approach to radiation damage caused by irradiation of a tissue with energetic ions and report the most recent advances in the calculations of complex DNA damage and the effects of thermal spikes on ...
Solov'yov, A. V., Surdutovich, E., Yakubovich, A. V.   +2 more
core   +1 more source

Chemical Aspects of Clustered DNA Damage Induction by Ionising Radiation

Radiation Protection Dosimetry, 2002
Ionising radiation induces a variety of chemical modifications to DNA, ranging from simple, isolated lesions to clustered DNA damage, in which two or more lesions are formed within a few tens of base pairs by a single radiation track. Multiple lesions, e.g. tandem lesions and amplification of damage, may also be induced in DNA by reaction with a single
Lomax, M, Gulston, M, O'Neill, P
openaire   +3 more sources

Analysis of acid-stressed Bacillus cereus reveals a major oxidative response and inactivation-associated radical formation [PDF]

, 2010
Acid stress resistance of the food-borne human pathogen Bacillus cereus may contribute to its survival in acidic environments, such as encountered in soil, food and the human gastrointestinal tract. The acid stress responses of B.
Abee, T., Kranenburg, R., van, Melis, C.C.J., van, Moezelaar, R., Mols, J.M.   +4 more
core   +2 more sources

Differences in microbiota between two multilocus lineages of the sugarcane Aphid (Melanaphis sacchari) in the continental United States [PDF]

, 2020
The sugarcane aphid (SCA), Melanaphis Sacchari (Zehntner) (Hemiptera: Aphididae), has been considered an invasive pest of sugarcane in the continental United States since 1977. Then, in 2013, SCA abruptly became a serious pest of U.S.
Antwi, Josephine B., Armstrong, John Scott, Costet, Laurent, Holt, Jocelyn R., Malacrinò, Antonino, McLaren, Neal, Medina, Raul F., Nibouche, Samuel, Peterson, Garry, Styer, Alex, White, Jennifer A., Wulff, Jason   +11 more
core   +1 more source

Significance of DNA polymerase I in in vivo processing of clustered DNA damage

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2013
We examined the biological consequences of bi-stranded clustered damage sites, consisting of a combination of DNA lesions, such as a 1-nucleotide gap (GAP), an apurinic/apyrimidinic (AP) site, and an 8-oxo-7,8-dihydroguanine (8-oxoG), using a bacterial plasmid-based assay.
Shikazono, N, Akamatsu, K, Takahashi, M, Noguchi, M, Urushibara, A, O'Neill, P, Yokoya, A   +6 more
openaire   +4 more sources

Proton Irradiation Increases the Necessity for Homologous Recombination Repair Along with the Indispensability of Non-Homologous End Joining

Cells, 2020
Technical improvements in clinical radiotherapy for maximizing cytotoxicity to the tumor while limiting negative impact on co-irradiated healthy tissues include the increasing use of particle therapy (e.g., proton therapy) worldwide.
Klaudia Szymonowicz, Adam Krysztofiak, Jansje van der Linden, Ajvar Kern, Simon Deycmar, Sebastian Oeck, Anthony Squire, Benjamin Koska, Julian Hlouschek, Melanie Vüllings, Christian Neander, Jens T. Siveke, Johann Matschke, Martin Pruschy, Beate Timmermann, Verena Jendrossek   +15 more
doaj   +1 more source

Direct observation of damage clustering in irradiated DNA with atomic force microscopy [PDF]

Nucleic Acids Research, 2019
Abstract Ionizing radiation produces clustered DNA damage that contains two or more lesions in 10–20 bp. It is believed that the complexity of clustered damage (i.e., the number of lesions per damage site) is related to the biological severity of ionizing radiation. However, only simple clustered damage containing two vicinal lesions has
Xu Xu, Toshiaki Nakano, Masataka Tsuda, Ryota Kanamoto, Ryoichi Hirayama, Akiko Uzawa, Hiroshi Ide   +6 more
openalex   +3 more sources