Results 71 to 80 of about 1,429,531 (305)

Correlation clustering with a fixed number of clusters [PDF]

Proceedings of the seventeenth annual ACM-SIAM symposium on Discrete algorithm - SODA '06, 2006
We continue the investigation of problems concerning correlation clustering or clustering with qualitative information, which is a clustering formulation that has been studied recently. The basic setup here is that we are given as input a complete graph on n nodes (which correspond to nodes to be clustered) whose edges are labeled + (for similar pairs ...
Ioannis Giotis 0001, Venkatesan Guruswami   +1 more
openaire   +4 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A clustering algorithm for ipsative variables

Dyna, 2019
The aim of this study is to introduce a new clustering method for ipsatives variables. This  method can be used for nominals or ordinals variables for which responses must be mutually exclusive, and it is independent of data distribution.
Jesica Rubiano Moreno, Carlos Alonso Malaver, Samuel Nucamendi Guillén, Carlos López Hernández   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

MACOC: a medoid-based ACO clustering algorithm [PDF]

, 2014
The application of ACO-based algorithms in data mining is growing over the last few years and several supervised and unsupervised learning algorithms have been developed using this bio-inspired approach. Most recent works concerning unsupervised learning
Otero, Fernando E. B., David Camacho, Héctor D. Menéndez, Otero, Fernando E.B., Camacho, David, Menendez, Hector, Menéndez, Héctor D., Fernando E. B. Otero   +7 more
core   +1 more source

cognitivefactory/interactive-clustering

, 2022
Release 0.5.2 of cognitivefactory/interactive-clustering package. GitHub repository : https://github.com/cognitivefactory/interactive-clustering/tree/0.5.2 Main documentation : https://cognitivefactory.github.io/interactive-clustering/ Pypi distribution
Schild, Erwan
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On the Elusiveness of Clusters

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2012
Rooted phylogenetic networks are often used to represent conflicting phylogenetic signals. Given a set of clusters, a network is said to represent these clusters in the "softwired" sense if, for each cluster in the input set, at least one tree embedded in the network contains that cluster.
S.M. Kelk (Steven), C. Scornavacca, L.J.J. van Iersel (Leo)   +2 more
openaire   +4 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

A first vocal repertoire characterization of long-finned pilot whales (Globicephala melas) in the Mediterranean Sea: a machine learning approach

Royal Society Open Science
The acoustic repertoires of long-finned pilot whales (Globicephala melas) in the Mediterranean Sea are poorly understood. This study aims to create a catalogue of calls, analyse acoustic parameters, and propose a classification tree for future research ...
M. Poupard, P. Best, J. P. Morgan, G. Pavan, H. Glotin   +4 more
doaj   +1 more source