Results 71 to 80 of about 1,206,915 (318)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Clustering with Same-Cluster Queries
CoRR, 2016 NIPS ...
Hassan Ashtiani +2 more
openaire +3 more sources
Open innovation: a research framework and case study of Huawei
Technological and Economic Development of Economy, 2023 Open innovation (OI) has received significant attention from practices and theories over the past decades. This paper investigates the role of OI and personalized patterns in firms at home and abroad, and then measures the risks involved.
Bo Li +4 more
doaj +1 more source
DDG-clustering: a novel technique for highly accurate results [PDF]
, 2009 A key to the success of any clustering algorithm is the similarity measure applied. The similarity among different instances is defined according to a particular criterion.
Gaber, Mohamed Medhat +3 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Frontiers in Neurology, 2023 IntroductionHuntington's disease (HD) is a rare neurodegenerative disease characterized by cognitive, behavioral and motor symptoms that progressively worsen with time.
Jinnie Ko +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Correlation clustering with a fixed number of clusters [PDF]
Proceedings of the seventeenth annual ACM-SIAM symposium on Discrete algorithm - SODA '06, 2006 We continue the investigation of problems concerning correlation clustering or clustering with qualitative information, which is a clustering formulation that has been studied recently. The basic setup here is that we are given as input a complete graph on n nodes (which correspond to nodes to be clustered) whose edges are labeled + (for similar pairs ...
Ioannis Giotis 0001 +1 more
openaire +3 more sources
The process of clustering in Russia: dynamics and regional features of development
Журнал Белорусского государственного университета: География, геология, 2017 This article analyzes the characteristics of the formation of clusters and cluster policy in Russia’s regions. Improving the efficiency of the organization of the economic territory of the space – is the most important problem of the modern development ...
Tatiana F. Krejdenko +2 more
doaj