Results 41 to 50 of about 242,831 (264)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A graph clustering algorithm based on a clustering coefficient for weighted graphs [PDF]
Journal of the Brazilian Computer Society, 2010 Abstract Graph clustering is an important issue for several applications associated with data analysis in graphs. However, the discovery of groups of highly connected nodes that can represent clusters is not an easy task. Many assumptions like the number of clusters and if the clusters are or not balanced, may need to be made before the ...
Mariá Cristina Vasconcelos Nascimento +1 more
openaire +1 more source
Modeling Bilingual Lexical Processing Through Code-Switching Speech: A Network Science Approach
Frontiers in Psychology, 2021 The study of code-switching (CS) speech has produced a wealth of knowledge in the understanding of bilingual language processing and representation. Here, we approach this issue by using a novel network science approach to map bilingual spontaneous CS ...
Qihui Xu +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Corrected Overlap Weight and Clustering Coefficient [PDF]
, 2019 The paper is a detailed and extended version of the talk presented at the CMStatistics (ERCIM) 2015 ...
openaire +2 more sources
Cluster automorphism groups of cluster algebras with coefficients [PDF]
Science China Mathematics, 2016 We study the cluster automorphism group of a skew-symmetric cluster algebra with geometric coefficients. For this, we introduce the notion of gluing free cluster algebra, and show that under a weak condition the cluster automorphism group of a gluing free cluster algebra is a subgroup of the cluster automorphism group of its principal part cluster ...
Chang, Wen, Zhu, Bin
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Frontiers in Human Neuroscience, 2015 We investigate the long-term evolution of degree-degree correlations (assortativity) in functional brain networks from epilepsy patients. Functional networks are derived from continuous multi-day, multi-channel electroencephalographic data, which capture
Christian eGeier +5 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2021 Impairment in spatial navigation (SN) and structural network topology is not limited to patients with Alzheimer’s disease (AD) dementia and can be detected earlier in patients with mild cognitive impairment (MCI). We recruited 32 MCI patients (65.91 ± 11.
Weiping Li +12 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source