Results 41 to 50 of about 16,106 (265)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis

Frontiers in Molecular Neuroscience
The growth cone, a motile structure located at the tip of growing axons, senses extracellular guidance cues and translates them into directional forces that drive axon outgrowth and guidance.
Zhen Qiu, Takunori Minegishi, Daichi Aoki, Kouki Abe, Kentarou Baba, Naoyuki Inagaki   +5 more
doaj   +1 more source

Development of High Efficiency Dog Clutch with One-Way Mechanism for Stepped Automatic Transmissions

International Journal of Automotive Engineering, 2019
In order to reduce drag losses and a clutch actuator load, the new dog clutch system for stepped automatic transmission is developed. Transmitting torque is converted to the engaging force because rotating shaft and dog clutch are connected with the ...
Isamu Shiotsu, Hirofumi Tani, Masanobu Kimura, Yu Nozawa, Atsushi Honda, Motoki Tabuchi, Hirotsugu Yoshino, Kentaroh Kanzaki   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Providing a Given Value of the Coefficient of Friction in the Gear Shifting of Mechanical Transmission

Механика машин, механизмов и материалов, 2010
The authors propose a method for reducing the loading of mechanical transmission in the shift in the use of microprocessor controller for the compensation of the friction coefficient of the friction clutch during its skid.
V.N. Basalaev
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analysis of Hydromechanical Transmission Friction Clutch Failures and Ways to Reduce them

Механика машин, механизмов и материалов, 2011
The author determines the main failures of BELAZ hydromechanical transmission; describes the design of hydromechanical transmission friction clutches as well as the types and causes of their failures.
O.A. Shapovalova , A.V. Leshok
doaj  

Estimation of Genetic Parameters for Egg Production and Clutch Traits in Lindian Chickens

Animals
To accelerate breeding progress for egg production traits in Lindian chickens, the genetic parameters for egg production and clutch-related traits in Lindian chickens were evaluated in the present study.
Jiacheng Liu, Fei Liang, Changsheng Sun, Xu Wang, Zhiyong Su, Yumao Li, Peng Luan, Zhiping Cao, Xue Bai, Li Leng   +9 more
doaj   +1 more source