Results 51 to 60 of about 40,506 (250)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Mathematical modelling of insect oviposition behaviour [PDF]
, 1998 This thesis is concerned with various aspects of insect oviposition behaviour. In the first chapter published mathematical models developed to understand optimal insect oviposition behaviour are reviewed.
Baring-Gould, Simone
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Adhesion-clutch between DCC and netrin-1 mediates netrin-1–induced axonal haptotaxis
Frontiers in Molecular NeuroscienceThe growth cone, a motile structure located at the tip of growing axons, senses extracellular guidance cues and translates them into directional forces that drive axon outgrowth and guidance.
Zhen Qiu +5 more
doaj +1 more source
Sex allocation and reproductive costs in a gull with a long breeding season [PDF]
, 2004 The Silver Gull is a small gull (265 - 450g), which exhibits sexual dimorphism, with males larger than females. It has a protracted laying period of about 8 months over the winter on Penguin Island in Western Australia.
Lamont, Christine Rae
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Механика машин, механизмов и материалов, 2010 The authors propose a method for reducing the loading of mechanical transmission in the shift in the use of microprocessor controller for the compensation of the friction coefficient of the friction clutch during its skid.
V.N. Basalaev
doaj
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Analysis of Hydromechanical Transmission Friction Clutch Failures and Ways to Reduce them
Механика машин, механизмов и материалов, 2011 The author determines the main failures of BELAZ hydromechanical transmission; describes the design of hydromechanical transmission friction clutches as well as the types and causes of their failures.
O.A. Shapovalova , A.V. Leshok
doaj