Results 71 to 80 of about 33,738 (312)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Effect of timing and female quality on clutch size in the Collared Flycatcher Ficedula albicollis

open access: yes, 2004
Capsule: Laying date and female age appear to be related to clutch size. Aims: To test two hypotheses ('date' and 'quality'), which might explain why fewer eggs are laid late in the season.
Tóth, László   +2 more
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Providing a Given Value of the Coefficient of Friction in the Gear Shifting of Mechanical Transmission

open access: yesМеханика машин, механизмов и материалов, 2010
The authors propose a method for reducing the loading of mechanical transmission in the shift in the use of microprocessor controller for the compensation of the friction coefficient of the friction clutch during its skid.
V.N. Basalaev
doaj  

Development of High Efficiency Dog Clutch with One-Way Mechanism for Stepped Automatic Transmissions

open access: yesInternational Journal of Automotive Engineering, 2019
In order to reduce drag losses and a clutch actuator load, the new dog clutch system for stepped automatic transmission is developed. Transmitting torque is converted to the engaging force because rotating shaft and dog clutch are connected with the ...
Isamu Shiotsu   +7 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Intracellulárisan jelzett 4. rétegi kis kosársejt („clutch” cell) axon- és dendritfájának 3-dimenziós fénymikroszkópos rekonstrukciója a macska primer látókéregben

open access: yes, 2017
A kis kosársejtek osztályának sajátos altípusa a „clutch” sejt. A „clutch” sejt egy közepes méretű multipoláris idegsejt típus, mely macska és majom elsődleges látókérgének IV. rétegében található meg.
Szűrösová, Tünde
core  

Analysis of Hydromechanical Transmission Friction Clutch Failures and Ways to Reduce them

open access: yesМеханика машин, механизмов и материалов, 2011
The author determines the main failures of BELAZ hydromechanical transmission; describes the design of hydromechanical transmission friction clutches as well as the types and causes of their failures.
O.A. Shapovalova , A.V. Leshok
doaj  

Estimation of Genetic Parameters for Egg Production and Clutch Traits in Lindian Chickens

open access: yesAnimals
To accelerate breeding progress for egg production traits in Lindian chickens, the genetic parameters for egg production and clutch-related traits in Lindian chickens were evaluated in the present study.
Jiacheng Liu   +9 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

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