Results 91 to 100 of about 16,531 (263)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Optimization Design of Integrated Axle Housing Electromagnetic Clutch with Heavy Load based on Uniform Design Theory

open access: yesJixie chuandong, 2016
In order to solve the problems of low transmission efficiency,large moment inertia of new type integrated axle housing electromagnetic clutch with heavy load,the integrated axle housing electromagnetic clutch is regarded as the research object,the ...
Zhou Hongru
doaj  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

新型重载摩擦离合器

open access: yesJixie chuandong, 2004
A modern version friction clutch is introduced. Friction coefficient of the clutch is 10-30 times larger than that of the common friction clutch. There are a lot of advantage of the clutch, such as the volume is small, power transmitted is great, the ...
梁以德, 梁慧芳
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Simulation of the Electro-hydraulic Control of Wet Clutch Actuator

open access: yesJixie chuandong, 2015
To the problems of strong nonlinear,time delay and lower control accuracy of wet clutch actuator,an automobile automatic transmission with wet clutch actuator is studied,according to the characteristics of the wet clutch and control strategy requirement ...
Zhang Zengliang
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

基于滑模变结构的DCT车辆双离合器起步控制研究

open access: yesJixie chuandong, 2014
By analyzing the structure characteristics of dual-clutch transmission(DCT)and using the Matlab/Simmechincs,the physical model of DCT is established.Through analyzing the relation of engine torque and engine speed,the constant speed starting is achieved ...
孔慧芳, 周达, 鲍伟, 尹良杰
doaj  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

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