Results 11 to 20 of about 195,243 (312)
The chronic myeloid leukemia stem cell: stemming the tide of persistence [PDF]
, 2017 Chronic myeloid leukaemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a haemopoietic stem cell (HSC), transforming it into a leukaemic stem cell (LSC) that self-renews, proliferates and differentiates to give rise to a ...
Holyoake, Tessa L., Vetrie, David
core +1 more source
Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression
Hepatology, EarlyView., 2022 Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández +18 more
wiley +1 more source
A Comparison Between Global Nutrient Retention Models for Freshwater Systems
Frontiers in Water, 2022 Against the backdrop of increasing agricultural production, population, and freshwater/coastal eutrophication, studies are aiming to understand the behavior of nitrogen (N) and phosphorus (P) in the global freshwater system.
Jinhui Zhou +5 more
doaj +1 more source
CML: the commonKADS conceptual modelling language [PDF]
, 1994 We present a structured language for the specification of knowledge models according to the CommonKADS methodology. This language is called CML (Conceptual Modelling Language) and provides both a structured textual notation and a diagrammatic notation ...
Akkermans, J.M. +5 more
core +2 more sources
Hepatology, EarlyView., 2022 Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel +93 more
wiley +1 more source
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]
, 2018 The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core +1 more source
Assessing circularity interventions: a review of EEIOA-based studies
Journal of Economic Structures, 2018 Environmentally extended input–output analysis (EEIOA) can be applied to assess the economic and environmental implications of a transition towards a circular economy. In spite of the existence of several such applications, a systematic assessment of the
Glenn A. Aguilar-Hernandez +4 more
doaj +1 more source
Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of β-catenin and mTORC1/2. [PDF]
, 2016 CML is effectively treated with tyrosine kinase inhibitors (TKIs). However, the efficacy of these drugs is confined to the chronic phase of the disease and development of resistance to TKIs remains a pressing issue.
Calabretta, Bruno +10 more
core +2 more sources
Evaluating crop-specific responses to salinity and drought stress from remote sensing
International Journal of Applied Earth Observations and Geoinformation, 2023 Food security is projected to be threatened by increasing co-occurring stresses (e.g., drought and salinity) under global climate change. To mitigate major impacts on food production, the tolerances and vulnerabilities of crops to these threats need to ...
Wen Wen +3 more
doaj +1 more source
Future material demand for automotive lithium-based batteries
Communications Materials, 2020 Lithium-ion-based batteries are a key enabler for the global shift towards electric vehicles. Here, considering developments in battery chemistry and number of electric vehicles, analysis reveals the increasing amounts of lithium, cobalt and nickel that ...
Chengjian Xu +5 more
doaj +1 more source