Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal [PDF]
, 2018 Leukaemic stem cell (LSC) persistence remains a major obstacle to curing chronic myeloid leukaemia (CML). The bone morphogenic protein (BMP) pathway is deregulated in CML, with altered expression and response to the BMP ligands shown to impact on LSC ...
Busch, Caroline +6 more
core +2 more sources
Moving treatment-free remission into mainstream clinical practice in CML.
Blood, 2016 The dramatic success of tyrosine kinase inhibitors (TKIs) has led to the widespread perception that chronic myeloid leukemia (CML) has become another chronic disease, where lifelong commitment to pharmacologic control is the paradigm.
T. Hughes, D. Ross
semanticscholar +1 more source
Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia [PDF]
, 2014 Chronic myeloid leukemia (CML) is a stem cell (SC) neoplasm characterized by the BCR/ABL1 oncogene. Although mechanisms of BCR/ABL1-induced transformation are well-defined, little is known about effector-molecules contributing to malignant expansion and ...
Bilban, Martin +15 more
core +1 more source
Assessing circularity interventions: a review of EEIOA-based studies
Journal of Economic Structures, 2018 Environmentally extended input–output analysis (EEIOA) can be applied to assess the economic and environmental implications of a transition towards a circular economy. In spite of the existence of several such applications, a systematic assessment of the
Glenn A. Aguilar-Hernandez +4 more
doaj +1 more source
The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells
Molecular Cancer, 2018 Chronic myeloid leukemia (CML) is a clonal disease characterized by the presence of the constitutively active tyrosine kinase BCR-ABL oncoprotein. Although BCR-ABL is crucially important for pathogenesis and treatment response, it is thought that some ...
Chengwu Zeng +10 more
semanticscholar +1 more source
Managing chronic myeloid leukemia for treatment-free remission: a proposal from the GIMEMA CML WP.
Blood Advances, 2019 Several papers authored by international experts have proposed recommendations on the management of BCR-ABL1+ chronic myeloid leukemia (CML). Following these recommendations, survival of CML patients has become very close to normal.
M. Baccarani +60 more
semanticscholar +1 more source
Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia [PDF]
, 2017 Since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, and dasatinib, chronic myelogenous leukemia (CML) prognosis has improved greatly. However, ~30-40% of patients develop resistance to imatinib therapy.
Bandyopadhyay, Shovik +6 more
core +3 more sources
Future material demand for automotive lithium-based batteries
Communications Materials, 2020 Lithium-ion-based batteries are a key enabler for the global shift towards electric vehicles. Here, considering developments in battery chemistry and number of electric vehicles, analysis reveals the increasing amounts of lithium, cobalt and nickel that ...
Chengjian Xu +5 more
doaj +1 more source
Maritime Anomaly Detection for Vessel Traffic Services: A Survey
Journal of Marine Science and Engineering, 2023 A Vessel Traffic Service (VTS) plays a central role in maritime traffic safety. Regulations are given by the International Maritime Organization (IMO) and Guidelines by the International Association of Marine Aids to Navigation and Lighthouse Authorities
Thomas Stach +3 more
doaj +1 more source
Evaluation of secreted frizzled-related protein-4 methylation profiles in patients with BCR/ABL positive chronic myeloid leukemia [PDF]
World Cancer Research Journal, 2021 Objective: Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder characterized by the chromosomal translocation t(9;22) encoding for the Bcr/Abl fusion gene.
M. Pehlivan +4 more
doaj +1 more source