Results 111 to 120 of about 570,811 (281)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Highlights from CMS

Nuclear Physics A, 2013
AbstractThe CMS collaboration has used a data set of 1 billion PbPb collisions at the LHC to study the behavior of strongly interacting matter at high temperature. In this Paper, we present selected recent highlights from this effort, with a particular emphasis on results related to the hydrodynamic expansion of the produced matter, the energy loss of ...
openaire   +3 more sources

UNEP/CMS Raptors MoU

Пернатые хищники и их охрана, 2018
The Raptors MoU is implemented via an Action Plan that promotes an internationally co-ordinated approach to the conservation of African-Eurasian birds of prey, with the overall aim being to return and maintain these species in Favourable Conservation ...
Nick P. Williams
doaj  

R-Hadron and long lived particle searches at the LHC [PDF]

, 2007
If long lived charged particles exist, and produced at the LHC, they may travel with velocity significantly slower than the speed of light. This unique signature was not considered during the design of the LHC experiments, ATLAS and CMS.
Bressler, S.
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Anglikan (İngiliz) misyoner teşkilatlar

Bozok Üniversitesi İlahiyat Fakültesi Dergisi, 2016
Anglikan Kilisesi, İngiltere’nin resmi kilisesidir. Bu kilise dünya üzerinde her yere misyoner teşkilatları sayesinde yayılmıştır. Başlıca İngiliz misyoner teşkilatlar SPCK, USPG ve CMS’dir.
Resul Çatalbaş
doaj  

Research on a CMS protocol for the substation control layer

Zhejiang dianli
To achieve a domestically developed alternative to the manufacturing message specification （MMS） as the core communication technology for the substation control layer， the State Grid Corporation of China has established the communication message ...
SUN Zhijia, FAN Dongkai, LUO Laifeng, ZHOU Junfeng   +3 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

The CMS Experiment: Status and First Results

, 2010
After nearly two decades of design, construction and commissioning, the CMS detector was operated with colliding LHC proton beams for the first time in November 2009.
Mulders, Martijn
core