Results 141 to 150 of about 282,628 (342)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Maternal inheritance: A newpathway for the industrialization of plant breeding

Journal of Agriculture, Food and Environment
Animaginecharacter named CMS found in different plant species and has been utilized in hybrid cultivars development. CMS is linked to incorporation of specific fertility restoring genes, which are donated by the restorer line. In recent years,
Goswami G
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Autoencoder-based Anomaly Detection System for Online Data Quality Monitoring of the CMS Electromagnetic Calorimeter [PDF]

The CMS detector is a general-purpose apparatus that detects high-energy collisions produced at the LHC. Online data quality monitoring of the CMS electromagnetic calorimeter is a vital operational tool that allows detector experts to quickly identify ...
DELLA RICCA, G., ET AL (the CMS ECAL Group)   +1 more
core   +1 more source

Measurement of the top quark pole mass using $\mathrm{t\bar{t}}$+jet events in the dilepton final state in proton-proton collisions at $\sqrt{s}$ = 13 TeV

, 2022
A preprint version of the article is available at arXiv:2207.02270v2 [hep-ex], https://arxiv.org/abs/2207.02270v2 . Comments: Replaced with the published version. Added the journal reference and the DOI. All the figures and tables can be found at https://
Mondal, K, Moraes, A, Alves, GA, Jaramillo, J, Rendón, C, Coelho, E, Jeitler, M, Schöfbeck, R, Vanlaer, P, Da Silveira, GG, Vermassen, B, Brandao Malbouisson, H, Waltenberger, W, Chatterjee, S, Sahasransu, AR, De Moor, A, Wertz, S, Jain, S, Wulz, CE, Malara, A, Lowette, S, Da Costa, EM, Mikulec, I, Kello, T, Pitters, FM, Bols, ES, Tumasyan, A, Carvalho, W, Barroso Ferreira Filho, M, Schwarz, D, Postiau, N, Van Den Bossche, N, Kyberd, P, Clerbaux, B, Donertas, IS, Damanakis, K, Lemaitre, V, Makarenko, I, Dobur, D, Andrejkovic, JW, Wezenbeek, L, Bruno, G, Liko, D, Templ, S, Rejeb Sfar, H, Paredes, S, Giammanco, A, Schieck, J, Van Doninck, W, De Lentdecker, G, Hohov, D, Delcourt, M, Hussain, PS, Cole, JE, Reid, ID, Lee, K, Darwish, MR, Vannerom, D, Benecke, A, Knolle, J, Coldham, K, Roskas, C, Bury, F, Mestdach, G, Aldá Júnior, WL, Escalante Del Valle, A, Van Mechelen, P, Vischia, P, Dragicevic, M, Pétré, L, Bergauer, T, Tran, TT, Vanden Bemden, M, Skovpen, K, Janssen, T, Müller, D, Samalan, A, Paulitsch, P, Moortgat, S, Starling, E, Delaere, C, Rebello Teles, P, Prisciandaro, J, David, P, Mahdavikhorrami, M, Alves Gallo Pereira, M, Khan, A, Taliercio, A, Caputo, C, Vander Velde, C, Hensel, C, Krammer, N, El Faham, H, Tytgat, M, Tavernier, S, D’Hondt, J, Lambrecht, L, Niedziela, M, Morton, A, Adam, W, Chinellato, J, Lechner, L, Favart, L, Thomas, L, Jaffel, K   +104 more
core   +1 more source

Diboson production at CMS [PDF]

Proceedings of XVIII International Workshop on Deep-Inelastic Scattering and Related Subjects — PoS(DIS 2010), 2010
We present an analysis strategy based on Monte Carlo simulations for measuring the WW and WZ production cross sections in pp collisions with the CMS detector. We describe suitable requirements for background reduction and data-driven methods to estimate the remaining backgrounds.
openaire   +2 more sources

Engineering Analysis of CMS Casing

Механика машин, механизмов и материалов, 2014
In the article the methodological requirements that are indispensable for the implementation of construction documents for the production and operation of developed structures and facilities in order to support the transition of products into commodities
L.V. Larchenkov, O.N. Protasenia, I.O. Protasenia   +2 more
doaj  

A clinical comparison of high dose and low dose of Suxamethonium

Journal of College of Medical Sciences-Nepal, 2014
Background: Suxamethonium having its rapid onset and short duration of action makes this drug unique amongst the neuromuscular blocking drugs described so far.
RK Yadav, PC Majhi, D Tiwari
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Accelerating the CM method [PDF]

LMS Journal of Computation and Mathematics, 2012
AbstractGiven a prime q and a negative discriminant D, the CM method constructs an elliptic curve E/Fq by obtaining a root of the Hilbert class polynomial HD(X) modulo q. We consider an approach based on a decomposition of the ring class field defined by HD, which we adapt to a CRT setting. This yields two algorithms, each of which obtains a root of HD
openaire   +3 more sources