Results 181 to 190 of about 234,696 (305)

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Postnatal CMV Infection in Extremely Premature Newborns: A Single-Center Exploratory Study. [PDF]

Children (Basel)
Košiček R, Erčulj V, Kornhauser Cerar L, Bregant L, Petrovec M, Pokorn M, Spirovska A, Uršič T, Potokar UR, Grosek S.   +9 more
europepmc   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Safety and Immunogenicity of the Cytomegalovirus Vaccine mRNA-1647 in Healthy Adults: Results from a Phase 2, Randomized, Controlled, Dose-Finding Trial with Long-Term Extension Follow-Up Through Month 48. [PDF]

Vaccines (Basel)
Fierro C, Brune D, Leggett R, Peterson J, Lorenz B, Calabro Calheiros R, Lin J, Iyer AS, Wu K, Cao X, Kondapally A, Marsh S, Kalidindi S, Husson J, Panther L.   +14 more
europepmc   +1 more source

High Cytomegalovirus (CMV) DNAemia Predicts CMV Sequelae in Asymptomatic Congenitally Infected Newborns Born to Women With Primary Infection During Pregnancy.

Journal of Infectious Diseases, 2015
Gabriella Forner, D. Abate, C. Mengoli, G. Palù, N. Gussetti   +4 more
semanticscholar   +1 more source

Fouling‐Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Lentiviral vectors (LVVs) are widely used as gene‐delivery vehicles in cell and gene therapy, enabling stable integration of transgenes into target cells. However, efficient clarification of LVV harvest remains a major bottleneck in large‐scale manufacturing, as conventional depth filtration often results in significant product loss.
Dohyun Park, Alexander Bevacqua, Mingyang Cui, Marina Nichols, Jianzhu Chen, Jongyoon Han   +5 more
wiley   +1 more source

Autopsy-Confirmed CMV Adrenalitis With Bilateral Adrenal Hemorrhage Following Presumed Critical Illness-Related Corticosteroid Insufficiency During Prolonged ICU Stay: A Case Report. [PDF]

Case Rep Crit Care
Kanamitsu Y, Seino Y, Toyoda N, Sugiura Y, Takano T, Kunishima H, Sato Y, Izumo M, Fujitani S.   +8 more
europepmc   +1 more source

Organising for Circularity: An Empirical Analysis of Project Organising and the Development of Circular Economy Firm Capabilities

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms pursue the circular economy (CE) by using projects as organisational forms. However, the transformative role of project organising (PO) in developing circular firm capabilities (FC) remains underexplored. In this study, we examine the effects of PO on the development of critical circular FC in CE‐based firms. We draw on primary data from
Ambisisi Ambituuni, Hakeem Sunmola, Emmanouil Tyllianakis, Oluwaseun Kolade, Soroush Abolfathi, Muyiwa Oyinlola   +5 more
wiley   +1 more source

Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report. [PDF]

Front Immunol
Guo R, Chen Q, Kong L, Huang A, Li Y, Li C.   +5 more
europepmc   +1 more source

Sustainability Orientation and Entrepreneurial Performance in Resource‐Constrained Contexts

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how sustainability orientation shapes entrepreneurial performance in bottom‐of‐the‐pyramid (BoP) markets by theorizing responsible entrepreneurship as a central mechanism and BoP orientation as a contextual contingency. Using survey data from 283 small‐ and medium‐sized enterprises (SMEs) in Ghana, we integrate perspectives
George Obeng Dankwah, Hayford Amegbe, Dafleen Addrah, Oghogho Destina Ovuakporie, Lydia Nyankom Takyi, Samuel Adomako   +5 more
wiley   +1 more source