Results 51 to 60 of about 68,640 (273)

Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity

Translational Neurodegeneration
Background Tau is an intracellular protein that plays a crucial role in stabilizing microtubules. However, it can aggregate into various forms under pathological conditions and be secreted into the brain parenchyma.
Valentin Zufferey, Aatmika Barve, Enea Parietti, Luc Belinga, Audrey Bringaud, Yvan Varisco, Kerstin Fabbri, Francesca Capotosti, Paola Bezzi, Nicole Déglon, Pierre Marquet, Nicolas Preitner, Kevin Richetin   +12 more
doaj   +1 more source

Characterization of Droplet Formation in Ultrasonic Spray Coating: Influence of Ink Formulation Using Phase Doppler Anemometry and Machine Learning

Advanced Materials Technologies, EarlyView.
This study explores how machine learning models, trained on small experimental datasets obtained via Phase Doppler Anemometry (PDA), can accurately predict droplet size (D32) in ultrasonic spray coating (USSC). By capturing the influence of ink complexity (solvent, polymer, nanoparticles), power, and flow rate, the model enables precise droplet control
Pieter Verding, Danny E. P. Vanpoucke, Yunus T. Aksoy, Tobias Corthouts, Maria R. Vetrano, Wim Deferme   +5 more
wiley   +1 more source

Therapeutic effect of C-type natriuretic peptide on persistent pain in a rat knee arthritis model

Journal of Orthopaedic Surgery, 2023
Background Intra-articular injection of C-type natriuretic peptide (CNP) at the acute inflammatory stage suppressed fibrotic changes in the infrapatellar fat pad (IFP), articular cartilage degeneration, and persistent pain in a monoiodoacetic acid (MIA ...
Shoichi Hasegawa, Jae-Sung An, Jun Hino, Yusuke Amano, Yusuke Nakagawa, Kazumasa Miyatake, Hiroki Katagiri, Tomomasa Nakamura, Ichiro Sekiya, Hideyuki Koga, Kunikazu Tsuji   +10 more
doaj   +1 more source

Transport Spectroscopy of Symmetry-Broken Insulating States in Bilayer Graphene

, 2011
The flat bands in bilayer graphene(BLG) are sensitive to electric fields E\bot directed between the layers, and magnify the electron-electron interaction effects, thus making BLG an attractive platform for new two-dimensional (2D) electron physics[1-5 ...
A. H. MacDonald, AH Castro Neto, AS Mayorov, BE Feldman, C. N. Lau, C. Varma, CL Kane, D Xiao, D. Smirnov, E McCann, EA Henriksen, EV Castro, EV Castro, EV Gorbar, F Zhang, F Zhang, Fan Zhang, FDM Haldane, G Borghi, H Min, HK Min, I Martin, IF Herbut, J Jung, J Martin, J. Jung, J. Velasco, KS Novoselov, KS Novoselov, L. Jing, M Konig, M Mucha-Kruczynski, M. Bockrath, N Nagaosa, O Vafek, O Vafek, P. Kratz, R Nandkishore, R. Stillwell, RT Weitz, S Raghu, T Ohta, V. Aji, W Bao, W Bao, W. Bao, Y Barlas, Y Lemonik, Y Zhao, Y. Lee, YB Zhang   +50 more
core   +1 more source

Home Used, Patient Self-Managed, Brain-Computer Interface for Treatment of Central Neuropathic Pain in Spinal Cord Injury: Feasibility Study [PDF]

, 2017
Central Neuropathic Pain (CNP) is a frequent chronic condition in people with spinal cord injury (SCI). In a previous study, we showed that using laboratory brain-computer interface (BCI) technology for neurofeedback training, it is possible to reduce ...
Al-Taleb, M.K.H., Fraser, M., Purcell, M., Vuckovic, Aleksandra   +3 more
core   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

Cross‐Platform Biosensing of Immune Receptors Using Peptide‐Functionalized Graphene

Advanced Science, EarlyView.
A peptide‐functionalized graphene biosensor enables sensitive and selective detection of living immune cells. Targeting Formyl‐Peptide Receptor 2 (FPR2), the assay is demonstrated on model cells and primary human neutrophils. The same assay is applied to two complementary platforms: graphene‐enhanced surface plasmon resonance for optical benchmarking ...
Ahmar Hasnain, Heiko Heilmann, Annabel Pohl, Celine Weber, Bernd Bufe, Alexey Tarasov   +5 more
wiley   +1 more source

Effective Connectivity in Spinal Cord Injury-Induced Neuropathic Pain

Sensors, 2022
Aim: The aim of this study was to differentiate the effects of spinal cord injury (SCI) and central neuropathic pain (CNP) on effective connectivity during motor imagery of legs, where CNP is typically experienced.
Radha Kumari, Mohammed Jarjees, Ioana Susnoschi-Luca, Mariel Purcell, Aleksandra Vučković   +4 more
doaj   +1 more source

Environment-mediated structure, surface redox activity and reactivity of ceria nanoparticles [PDF]

, 2013
Nanomaterials, with potential application as bio-medicinal agents, exploit the chemical properties of a solid, with the ability to be transported (like a molecule) to a variety of bodily compartments.
Asati, Cornell, Das, Dean C. Sayle, Feng, Gale, Günter Möbus, Harding, Humphrey, Jacobson, Karakoti, Mai, Marco Molinari, Migani, Mobus, Molinari, Momma, Nolan, Patil, Patil, Pedone, Sayle, Sayle, Sayle, Sayle, Shibata, Soumen Das, Stack, Stark, Stephen C. Parker, Sudipta Seal, Thi X. T. Sayle, Umananda M. Bhatta, Vyas, Walsh, Watson, Xu, Yoshida, Zhang, Zhang, Zhou   +40 more
core   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source