Results 91 to 100 of about 4,840 (178)

Dissection of genetic associations with language-related traits in population-based cohorts [PDF]

, 2011
The author was supported by the Wellcome Trust [076566/Z/05/Z]; [075491/Z/04] and the Medical Research Council [G0800523/86473].Recent advances in the field of language-related disorders have led to the identification of candidate genes for specific ...
Paracchini, Silvia, Silvia Paracchini
core   +1 more source

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme, Rocio K. Finol‐Urdaneta, Jeffrey R. McArthur, Nicholas R. Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J. Adams, Mirella Dottori   +12 more
wiley   +1 more source

Long-Term Effects of Early Postnatal Administration of R-Baclofen on Neuronal Properties in the Cntnap2 Knockout Rat

Journal of Integrative Neuroscience
Background:Contactin-associated protein-like 2 (Cntnap2) is a highly expressed gene during development, coding for the cell adhesion molecule CASPR2. Loss-of-function of Cntnap2 leads to a neurodevelopmental disorder that presents with the core symptoms ...
Hannah Pineda, Susanne Schmid
doaj   +1 more source

Mapping the Scientific Landscape of Schizophrenia Genetics (2020–2025): A Bibliometric and Scientometric Study of Global Trends and Collaborations

Brain and Behavior, Volume 16, Issue 1, January 2026.
This graphical abstract illustrates the integrated workflow of the study‐ Mmapping the Sscientific Llandscape of Sschizophrenia Ggenetics (2020‐2025). The process combines bibliometric and scientometric analyses of 5,001 publications using VOSviewer to identify thematic clusters, key contributors, and international collaboration networks that define ...
Niloofar Mikaeili, Mahdi Naeim, Mohammad Narimani   +2 more
wiley   +1 more source

Estrogens Suppress a Behavioral Phenotype in Zebrafish Mutants of the Autism Risk Gene, CNTNAP2 [PDF]

, 2016
Autism spectrum disorders (ASD) are a group of devastating neurodevelopmental syndromes that affect up to 1 in 68 children. Despite advances in the identification of ASD risk genes, the mechanisms underlying ASD remain unknown.
State, MW, Turner, Katherine J., Granato, M, Hoffman, E., Turner, K., Bill, B., Bill, Brent R., Giraldez, Antonio J., Turner, Katherine J, Ghosh, M., Giraldez, Antonio J, Wilson, SW, Wilson, Stephen W., Ijaz, Sundas, Barresi, MJF, Giraldez, A., Jain, Roshan A, Bill, Brent R, Turner, KJ, Fernandez, JM, Kubo, Fumi, Barresi, Michael J.F., Bill, BR, Hoffman, Ellen J., Kubo, F, Granato, M., State, Matthew W., Granato, Michael, Cifuentes, D., Ijaz, S., Wilson, S., Rihel, J, Hoffman, EJ, Giraldez, AJ, Baier, Herwig, Hoffman, Ellen J, Barresi, M., Barresi, Michael JF, State, Matthew W, Fernandez, Joseph M., Cifuentes, Daniel, Rihel, J., Cifuentes, D, Fernandez, Joseph M, Baier, H, Baier, H., Wilson, Stephen W, State, M., Jain, R., Kubo, F., Ijaz, S, Ghosh, Marcus, Rihel, Jason, Fernandez, J., Jain, RA, Ghosh, M, Jain, Roshan A.   +56 more
core   +1 more source

The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex

, 2021
The differing cognitive abilities of humans and other primates are accompanied by changes to forebrain neuronal circuit composition and function. This is underpinned by species-specific features of their development. Excitatory neurons in the human cerebral cortex have longer neurites and more elaborate neurite branching than chimpanzees or macaques ...
openaire   +1 more source

Calorie Restriction Attenuates Transcriptional Aging Signatures in White Matter Oligodendrocytes and Immune Cells of the Monkey Brain

Aging Cell, Volume 25, Issue 1, January 2026.
Our single nuclei RNA sequencing data reveal that long‐term calorie restriction in aged rhesus monkeys reduces neuroinflammation and preserves glial metabolism. In oligodendrocytes, calorie restriction attenuates an immune signature and promotes axonal proximity, while reducing a myelin‐laden microglia population.
Ana T. Vitantonio, Christina Dimovasili, Yuchen Liu, Bingtian Ye, Jou‐Hsuan Roxie Lee, Molly Hartigan, Benjamin Bouchard, Madelyn Ray, Bryce Conner, Kelli L. Vaughan, Julie A. Mattison, Tara L. Moore, Chao Zhang, Douglas L. Rosene   +13 more
wiley   +1 more source

Amino-Terminal Microdeletion within the CNTNAP2 Gene Associated with Variable Expressivity of Speech Delay

Case Reports in Genetics, 2012
The contactin-associated protein-like 2 (CNTNAP2) gene is highly expressed in the frontal lobe circuits in the developing human brain. Mutations in this gene have been associated with several neurodevelopmental disorders such as autism and specific ...
Amel Al-Murrani, Fern Ashton, Salim Aftimos, Alice M. George, Donald R. Love   +4 more
doaj   +1 more source

Interaction Effect between Handedness and CNTNAP2 Polymorphism (rs7794745 genotype) on Voice-specific Frontotemporal Activity in Healthy Individuals: An fMRI Study

Frontiers in Behavioral Neuroscience, 2015
Recent neuroimaging studies have demonstrated that Contactin-associated protein-like2 (CNTNAP2) polymorphisms affect left-hemispheric function of language processing in healthy individuals, but no study has investigated the influence of these ...
Michihiko eKoeda, Atsushi eWatanabe, Atsushi eWatanabe, Kumiko eTsuda, Miwako eMatsumoto, Yumiko eIkeda, Woochan eKim, Amane eTateno, Banyar Than eNaing, Banyar Than eNaing, Hiroyuki eKaribe, Takashi eShimada, Hidenori eSuzuki, Masato eMatsuura, Yoshiro eOkubo   +14 more
doaj   +1 more source

Expanding the clinical spectrum associated with defects in CNTNAP2 and NRXN1 [PDF]

, 2011
Background Heterozygous copy-number and missense variants in CNTNAP2 and NRXN1 have repeatedly been associated with a wide spectrum of neuropsychiatric disorders such as developmental language and autism spectrum disorders, epilepsy and schizophrenia ...

core   +5 more sources