Results 81 to 90 of about 4,840 (178)

Molecular Architecture of Contactin-associated Protein-like 2 (CNTNAP2) and Its Interaction with Contactin 2 (CNTN2)* [PDF]

, 2017
Contactin-associated protein-like 2 (CNTNAP2) is a large multidomain neuronal adhesion molecule implicated in a number of neurological disorders, including epilepsy, schizophrenia, autism spectrum disorder, intellectual disability, and language delay. We
Seshadrinathan, Suchithra, Liu, Jiankang, Rudenko, Gabby, Kalichava, Ana, Ren, Gang, Zhang, Lei, Liu, Jianfang, Chen, Fang, Zhong, Xiaoying, Holthauzen, Luis Marcelo F, White, Mark A, Lu, Zhuoyang, Wang, Yun, Reddy, MVVV Sekhar   +13 more
core   +1 more source

The development of positron emission tomography (PET) tracer for glutamate AMPA receptors and its application to human biology and clinics

Psychiatry and Clinical Neurosciences, Volume 80, Issue 5, Page 367-373, May 2026.
Psychiatric and neurological disorders severely compromised patients' quality of life. Despite their urgent needs, the development of diagnostics and therapeutics based on the biological basis has made only little progress. This is due to limited evidence on the biological basis of these disorders in humans. Synapses are fundamental structural units of
Mai Hatano, Hiroki Abe, Takuya Takahashi
wiley   +1 more source

Loss of Cntnap2 decreases specifically stabilization of new spines.

, 2015
a. From left to right: Chronic imaging through a cranial window of L5 pyramidal neuron. The 3 images on the right show the dynamics of spines on a dendrite segment followed for 11 days. b-e.
Peyman Golshani (85724), Joshua T. Trachtenberg (366144), Daniel H. Gescwind (736146), Amos Gdalyahu (3213810), Olga Penagarikano (736145), Maria Lazaro (736144)   +5 more
core   +1 more source

Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder. [PDF]

PLoS ONE, 2015
Autism spectrum disorder comprises several neurodevelopmental conditions presenting symptoms in social communication and restricted, repetitive behaviors.
Daniela Brunner, Patricia Kabitzke, Dansha He, Kimberly Cox, Lucinda Thiede, Taleen Hanania, Emily Sabath, Vadim Alexandrov, Michael Saxe, Elior Peles, Alea Mills, Will Spooren, Anirvan Ghosh, Pamela Feliciano, Marta Benedetti, Alice Luo Clayton, Barbara Biemans   +16 more
doaj   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Evidence for altered acetylcholine-evoked inhibition in the prefrontal cortex of Cntnap2-/- mice

Mutations in the CNTNAP2 gene cause neurological conditions like autism spectrum disorder (ASD) and epilepsy. The Cntnap2-/- ASD mouse model is reported to exhibit altered excitatory and inhibitory synaptic transmission.
Nielsen, Anna
core   +5 more sources

How copy number variations shape brain developmental disorders: Unraveling the synaptic puzzle

Psychiatry and Clinical Neurosciences, Volume 80, Issue 3, Page 166-179, March 2026.
Neurodevelopmental disorders (NDDs), such as schizophrenia (SCZ), Attention‐deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), learning disabilities, and intellectual disabilities (ID), are highly prevalent. One significant genetic factor associated with NDDs is copy number variations (CNVs), which are structural changes in the ...
Tianqi Wang, Kubra Trabzonlu, Emily Fullard Jones, Yasir Ahmed Syed   +3 more
wiley   +1 more source

Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity

, 2017
Variants in CNTNAP2, a member of the neurexin family of genes that function as cell adhesion molecules, have been associated with multiple neuropsychiatric conditions such as schizophrenia, autism spectrum disorder and intellectual disability; animal ...
Arthur J. Siegel, Deborah L. Levy, Elena Artimovich, Erin Flaherty, Inkyu S. Lee, Kristen J. Brennand, Michael W. Nestor, Rania M. Deranieh   +7 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, Volume 20, Issue 2, Page 282-306, February 2026.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

SA93. Deletion of CNTNAP2 and White Matter Changes in Schizophrenia [PDF]

Schizophrenia Bulletin, 2017
Abstract Background: Schizophrenia (SZ) is a severe mental disorder with heritability estimated at ~80%. Genetic variants in contactin-associated protein-like 2 (CNTNAP2) have been reported in SZ. This gene is critically involved in normal neuronal synchronization and myelin production. Deletions in this gene would therefore be expected to impact white
Atilla Gönenç, Panagiotis Douvaras, Arthur Siegel, David Olson, Uwe Rudolph, Valentina Fossati, Kristen Brennand, Deborah Levy   +7 more
openaire   +1 more source