Results 111 to 120 of about 408,394 (320)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Balanced Innovation Model. The case of Crowdfunding platforms. [PDF]
, 2019 Purpose – The paper aims to analyze balanced centricity (Gummesson, 2008) as an institutional arrangement (Vargo and Lusch, 2016) fostering the innovation process by taking out the customer from the central positioning to involve other business partners.
Quero-Gervilla, Maria Jose +1 more
core
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Collaborative Commerce Model for SMEs A Knowledge and Resources Sharing Mechanism for Co Creation
, 2022 Mardiana Purwaningsih +3 more
openalex +2 more sources
Customer engagement and value co-creation [PDF]
, 2015 Contemporary markets are increasingly interconnected , with actors no longer seen as part of linear value chains but existing in networks of service systems where interaction, collaboration and experience sharing take place (Jaakkola, Helkkula & Aarikka -
Alexander, Matthew, Jaakkola, Elina
core
Co-Creation and Sustainable Urban Planning: Who Co-Creates Sustainable Mobility Solutions at the Neighbourhood Level? Experiences from the Horizon 2020 Project “Sunrise” [PDF]
, 2020 Co-creation is applied as a key concept to develop, implement, assess, and facilitate learning about new ways to address urban mobility challenges at the neighbourhood level in the HORIZON 2020 project SUNRISE1(“Sustainable Urban Neighbourhoods ...
Franta, Lukas, Haufe, Nadine
core