Results 131 to 140 of about 425,470 (322)

Antecedents and Outcomes of Service Co-Creation in the Sharing Economy [PDF]

open access: gold, 2022
Felicitas Evangelista   +6 more
openalex   +1 more source

Value co-creation characteristics and creativity-oriented customer citizenship behavior [PDF]

open access: yes, 2013
For the competitive advantage of service organization, it is important to improve the creative performance of human resources in the organization. For example, when employees perform creatively, in other words, if they generate novel and useful ideas, it
Choi, Jin Nam   +2 more
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Customer engagement and value co-creation [PDF]

open access: yes, 2015
Contemporary markets are increasingly interconnected , with actors no longer seen as part of linear value chains but existing in networks of service systems where interaction, collaboration and experience sharing take place (Jaakkola, Helkkula & Aarikka -
Alexander, Matthew, Jaakkola, Elina
core  

Co-Creation and Sustainable Urban Planning: Who Co-Creates Sustainable Mobility Solutions at the Neighbourhood Level? Experiences from the Horizon 2020 Project “Sunrise” [PDF]

open access: yes, 2020
Co-creation is applied as a key concept to develop, implement, assess, and facilitate learning about new ways to address urban mobility challenges at the neighbourhood level in the HORIZON 2020 project SUNRISE1(“Sustainable Urban Neighbourhoods ...
Franta, Lukas, Haufe, Nadine
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

The Balanced Innovation Model. The case of Crowdfunding platforms. [PDF]

open access: yes, 2019
Purpose – The paper aims to analyze balanced centricity (Gummesson, 2008) as an institutional arrangement (Vargo and Lusch, 2016) fostering the innovation process by taking out the customer from the central positioning to involve other business partners.
Quero-Gervilla, Maria Jose   +1 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

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