Results 91 to 100 of about 9,897,717 (308)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
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Karte der Ansiedelungen am Hafen von Apia, Insel Upolo [cartographic material] /
, 1879 Plate 3 from: [Maps of Oceania by L.Friederichsen & Co., probably published in Mitteilungen der Geographischen Gesellschaft in Hamburg, 1879]. Hamburg : L. Friederichsen & Co., 1879.; Map of Apia, Samoa.
L. Friederichsen & Co.
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A Dialysis Membrane-Integrated Microfluidic Device for Controlled Drug Retention and Nutrient Supply
MicromachinesTraditional pre-clinical drug evaluation methods, including animal experiments and static cell cultures using human-derived cells, face critical limitations such as interspecies differences, ethical concerns, and poor physiological relevance.
Hajime Miyashita +4 more
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 1879 Plate 5 from: [Maps of Oceania by L.Friederichsen & Co., probably published in Mitteilungen der Geographischen Gesellschaft in Hamburg, 1879]. Hamburg : L. Friederichsen & Co., 1879.; Map of Gilbert Islands (Kiribati).
L. Friederichsen & Co.
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This volume introduces a new concept that boldly breaks through the traditional dichotomy of high and low culture while offering a fresh approach to both: unpopular culture.
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Rethinking Culture and Cultural Analysis
, 2013 The texts in this collection are revised versions of presentations given at the Coimbra International Conference on the Semantics of Culture emph Why ``Culture''?, held on November 24-25, 2011.
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The Activity of Human NK Cells Towards 3D Heterotypic Cellular Tumor Model of Breast Cancer
CellsDue to the complexity of modeling tumor-host interactions within the tumor microenvironment in vitro, we developed a 3D heterotypic cellular breast cancer (BC) model.
Anastasia Leonteva +9 more
doaj +1 more source
Stem Cell Reports, 2017 Astrocyte dysfunction and neuroinflammation are detrimental features in multiple pathologies of the CNS. Therefore, the development of methods that produce functional human astrocytes represents an advance in the study of neurological diseases.
Renata Santos +21 more
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Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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