Results 101 to 110 of about 1,207,245 (309)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Five year retrospective study on Syphilis in the Sexual Transmitted Disease (STD) centre of the teaching hospital Umberto I in Rome [PDF]

, 2018
Objectives: A retrospective study describing syphilis epidemiological and clinical features in patients referring to an infectious diseases centre in Rome, Italy.
Cinzia Conti, Elisabetta Schiariti, Giovanni Battista Orsi, NICOLAI, MATTEO, Paola Goldoni, Salvatore Pala, SILVAGGIO, DIONISIO   +6 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Estimating the burden of illness related to genital warts in the Philippines: a nationally representative cross-sectional study

Infectious Agents and Cancer, 2019
Background This study estimated genital warts prevalence, genital-warts-related healthcare resource use and costs, and self-reported human-papillomavirus-related psychosocial impact among male and female patients aged 18–60 years in the Philippines ...
Lani Buenconsejo, Smita Kothari-Talwar, Karen Yee, Amit Kulkarni, Nuria Lara, Montserrat Roset, Anna R. Giuliano, Suzanne Garland   +7 more
doaj   +1 more source

Trypanosoma brucei gambiense in domestic livestock of Kogo and Mbini foci (Equatorial Guinea).

, 2009
OBJECTIVE: To evaluate Trypanosoma brucei gambiense infection in peri-domestic livestock from Kogo and Mbini foci (Equatorial Guinea) in order to investigate its possible implication in the sleeping sickness transmission cycle in these hypoendemic foci ...
Benito, A, Berzosa, P, Bobuakasi, L, Buatiche, JN, Cano, J, Cordon-Obras, C, Ndong-Mabale, N, Ndongo-Asumu, P   +7 more
core   +1 more source

Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection [PDF]

, 2016
Tuberculosis (TB) causes significant morbidity and mortality on a global scale. The African region has 24% of the world's TB cases. TB overlaps with other infectious diseases such as malaria and HIV, which are also highly prevalent in the African region.
Al-Aska, Bhutta, Boccia, C. C. Onyenekwe, Cavalcanti, Centers for Disease Control and Prevention Grand Rounds, Cohen, Cooper, Couper, Day, Diedrich, Erhabor, Francischetti, G. I. Amilo, Geldmacher, Handzel, J. O. Okoye, Kumar, Kwan, L. Martinez-Pomares, Lalvani, Li, Mohan, Mueller, Murphy, N. R. Agbakoba, Newport, Olson, Onyenekwe, Orme, Ottenhoff, Page, R. C. Chukwuanukwu, R. Flynn, Raja, Restrepo, Riley, Roach, S. Singh, Sarrazin, Sasindran, Shaler, Sutherland, Vitoria, Wallis, World Health Organization (WHO), Zheng   +46 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Hepatic steatosis progresses faster in HIV mono-infected than HIV/HCV co-infected patients and is associated with liver fibrosis [PDF]

, 2017
Background & Aims Hepatic steatosis (HS) seems common in patients infected with human immunodeficiency virus (HIV). However, the relative effect of HIV, as well as hepatitis C virus (HCV) in those co-infected, and the influence of HS on liver fibrosis ...
Benmassaoud, Amine, Deschenes, Marc, Ghali, Peter, Halme, Alex, Klein, Marina B., Lebouché, Bertrand, Pembroke, Thomas, Pexos, Costa, Sebastiani, Giada, Sewitch, Maida, Vuille-Lessard, Elise, Wong, Philip   +11 more
core   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source